摘要
目的分析2014~2016年我院四肢创伤性骨折感染病原菌的分布及耐药性。方法选取2014年3月~2016年6月在我院确诊病原菌感染的80例四肢创伤性骨折患者(开放性骨折45例,闭合性骨折35例)作为研究对象,进行病历资料分析,考察病原菌分布及药敏结果。结果 80例患者中,单一病原菌感染75例(93.75%),混合感染5例(占6.25%)。共检出85株菌株,其中革兰阳性菌52株(占61.18%),革兰阴性菌33株(占38.82%)。金黄色葡萄球菌和表皮葡萄球菌对青霉素均具有耐药性,耐药率为100%,对替加环素和利奈唑胺不表现出耐药性。大肠埃希菌和阴沟肠杆菌对头孢唑啉均具有耐药性,耐药率为100%,阴沟肠杆菌对氨苄西林和舒巴坦的耐药率均为100%,大肠埃希菌对哌拉西林和红霉素均不表现出耐药性。结论我院2014~2016年四肢创伤性骨折感染病原菌以革兰阳性菌为主,临床治疗应结合具体药敏试验结果合理选用抗菌药物。
Objective To analyze the distribution and drug resistance of pathogenic bacteria in traumatic fractures of limbs in our hospital from 2014 to 2016.Methods Eighty patients of traumatic fracture of extremities（open fracture in45 cases and closed fracture in 35 cases）with confirmed pathogenic bacteria infection in our hospital from March 2014 to June 2016 were selected as subjects for medical record analysis.Pathogen distribution and drug susceptibility results were surveyed.Results Among the 80 patients,75 cases were single pathogenic bacteria（93.75%） and 5 cases were mixed infections（6.25%）.A total of 85 strains were detected,of which 52 strains were Gram-positive bacteria（61.18%）,33 strains were Gram-negative bacteria（accounting for 38.82%）.Staphylococcus aureus and Staphylococcus epidermidis were all resistant to Penicillin,the resistance rate was 100%,while the resistance did not show to Tigecycline and Linezolid.Escherichia coli and Enterobacter cloacae were resistant to Cefazolin,the resistance rate was 100%,and the resistance of Enterobacter cloacae to Ampicillin and Sulbactam were 100%,while Escherichia coli did not show resistance to Piperacillin and Erythromycin.Conclusions Gram-positive bacteria are the main pathogenic bacteria of traumatic fractures of limbs in our hospital from 2014 to 2016.The clinical treatment should be combined with specific drug susceptibility test results to choose antibacterial drugs.
作者
沈丽花
陈碧青
SHEN Li-hua;CHEN Bi-qing(Department of Pharmacy,Zhanjiang Central People＇s Hospital,Guangdong Province,Zhanjiang 524037,Chin)
出处
《中国当代医药》
2018年第12期92-94,共3页
China Modern Medicine
关键词
四肢创伤性骨折
病原菌
分布
耐药性
Traumatic fracture of limbs
Pathogen
Distribution
Drug resistance
