摘要
目的研究IL-2与IL-13细胞因子动态变化在儿童肺炎支原体肺炎(MPP)发病中的作用及机制,为医护人员掌握MPP患儿的免疫状态,合理调整IL-2与IL-13水平提供理论依据。方法采用纵向研究设计方法,选取2013年6月-2015年7月在深圳市福田区妇幼保健院就诊的MPP患儿180例为试验组,均符合幼儿MPP诊断标准。选取正常幼儿156例为对照组。抽取两组人员的静脉血,检测血清IL-2与IL-13水平,研究MPP免疫学发病机制。结果检测两组人员血清细胞因子IL-2、IL-13的浓度,免疫球蛋白Ig G、Ig A、Ig M,补体C3、C4及外周T淋巴细胞亚群CD3^+、CD4^+、CD8^+,发现MPP患者急性期IL-2检测水平明显低于对照组和恢复期,而IL-13检测水平MPP急性期明显高于对照组及MPP恢复期;MPP急性期、恢复期免疫球蛋白Ig G检测水平与对照组差异无统计学意义(P>0.05);试验组MPP急性期免疫球蛋白Ig M和补体C3、C4检测水平明显高于对照组及MPP恢复期,而MPP急性期、恢复期免疫球蛋白Ig A检测水平明显低于对照组;MPP急性期、恢复期外周T淋巴细胞亚群CD3^+、CD4^+、CD8^+检测水平明显低于对照组,差异有统计学意义(P<0.05)。结论 MPP患儿免疫系统水平降低,研究MPP细胞因子动态变化及MPP免疫学发病机制可提高患儿的康复率,对婴幼儿临床诊治具有一定的指导意义。
Objective To research the role of dynamic changes of IL-2 and IL-13 levels in pathogenesis of Mycoplasma pneumoniae pneumonia（ MPP） in children and the mechanism,provide a theoretical basis for mastery of immune status of MPP children and reasonable adjustment of IL-2 and IL-13 levels by the medical workers. Methods A longitudinal study was performed,180 children with MPP treated in Maternal and Child Health Care Hospital of Futian District from June 2013 to July 2015 were selected as experimental group,all the children met the diagnostic criteria of MPP; 156 normal children were selected as control group. Venous blood samples of children in the two groups were abstracted,the levels of serum IL-2 and IL-13 were detected,the immunological mechanism of MPP in children was studied.Results The level of IL-2 in the acute phase in experimental group was significantly lower than those in control group and in the recovery phase in experimental group,while the level of IL-13 in the acute phase in experimental group was significantly higher than those in control group and in the recovery phase in experimental group. There was no statistically significant difference in the level of IgG between experimental group in the acute phase and recovery phase and control group（ P〈0. 05）. The levels of IgM,C3,and C4 in the acute phase in experimental group was significantly higher than those in control group and in the recovery phase in experimental group,while the levels of IgA in experimental group in the acute phase and recovery phase were significantly lower than that in control group. The levels of CD3＋,CD4＋,and CD8＋T lymphocytes subsets in experimental group in the acute phase and recovery phase were statistically significantly lower than those in control group（ P〈0. 05）. Conclusion The level of immune system in MPP children decreases,researching the dynamic changes of cytokines and immunological mechanism of MPP can improve recovery rate of these children,which has a certain guiding significance for clinical diagnosis and treatment.
作者
蔡泽波
杜江滨
CAI Ze-Bo;DU Jiang-Bin(Department of Pediatrics, Maternal and Child Health Care Hospital of Futian District, Shenzhen, Guangdong 518000, China)
出处
《中国妇幼保健》
CAS
2018年第8期1778-1780,共3页
Maternal and Child Health Care of China
