摘要
目的:观察复方伤痛胶囊结合后路内固定术治疗胸腰椎骨折患者的临床疗效及其对纤维蛋白原(FIB)、神经功能和血清炎症因子的影响。方法:将116例胸腰椎骨折患者按照随机数字表法分为2组各58例,2组均给予健康教育和饮食指导,在此基础上对照组给予后路内固定术治疗,观察组在对照组治疗方案的基础上联合复方伤痛胶囊治疗。观察2组中医证候积分、疼痛程度、日常生活能力、神经功能、临床疗效,检测FIB、肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)、白细胞介素-6(IL-6)。结果:治疗后,2组中医证候积分、疼痛视觉模拟评分量表(VAS)评分、美国国立卫生院卒中量表(NIHSS)评分、血FIB、TNF-α、IL-2、IL-6水平均低于治疗前,ADL评分高于治疗前,差异均有统计学意义(P<0.05,P<0.01);观察组中医证候积分、VAS评分、NIHSS评分、ADL评分、血FIB、TNF-α、IL-2、IL-6水平分别与对照组比较,差异均有统计学意义(P<0.05,P<0.01)。总有效率观察组94.83%,高于对照组82.76%,差异有统计学意义(P<0.05)。结论:复方伤痛胶囊结合后路内固定术可有效提高胸腰椎骨折患者神经功能和日常生活能力,改善FIB和血清炎症因子水平,提高临床疗效。
Objective：To observe the clinical effect of Fufang Shangtong capsules combined with posterior internal fixation for thoracolumbar fracture and its effect on fibrinogen（FIB）,nerve function and serum inflammatory factors. Methods：Divided 116 cases of patients with posterior internal fixation into two groups randomly according to random number table,58 cases in each group. Based on treatment of health education and diet guidance in two groups,the control group received posterior internal fixation for treatment,while the observation group received posterior internal fixation combined with Fufang Shangtong capsules. Observed Chinese medicine syndrome scores,pain degree,activity of daily living,nerve function as well as clinical effect,and detected FIB,tumor necrosis factor-α（TNF-α）,interleukin-2（IL-2） and interleukin-6（IL-6） in both groups. Results：After treatment,scores of Chinese medicine syndrome,visual analogue scales（VAS） and National Institutes of Health stroke scale（NIHSS） as well as levels of blood FIB,TNF-α,IL-2 and IL-6 in both groups were lower than those before treatment,while ADL scores were higher than those before treatment,differences being significant（P〈0.05,P〈0.01）. The respective comparisons of scores of Chinese medicine syndrome,VAS,NIHSS and ADL as well as levels of blood FIB,TNF-α,IL-2 and IL-6 between the two groups showed significance in differences（P〈0.05,P〈0.01）.The total effective rate was 94.83% in the observation group,remarkably higher than that in the control group which was 82.76%,the difference being significant（P〈0.05）. Conclusion：The therapy of Fufang Shangtong capsules combined with posterior internal fixation can effectively improve nerve function and activity of daily living of patients with thoracolumbar fracture,and improves levels of blood FIB and serum inflammatory factors as well as improves clinical effect.
作者
罗晓
李晶
李毓吉
左可斌
LUO Xiao;LI Jing;LI Yuji;ZUO Kebin
出处
《新中医》
CAS
2018年第3期115-119,共5页
New Chinese Medicine
基金
甘肃省自然科学基金资助项目(15RJZA076)
关键词
胸腰椎骨折
复方伤痛胶囊
后路内固定术
纤维蛋白原
神经功能
炎症因子
Thoracolumbar fracture
Fufang Shangtong capsules
Posterior internal fixation
Fibrinogen, Nerve functionInflammatory factors
