摘要
目的观察自拟消炎利胆汤对急性梗阻性化脓性胆管炎患者(肝胆湿热证)肝功能和炎症因子的影响,并探讨其机制。方法将患者94例按照随机数字表法分为治疗组与对照组各47例,对照组给予抗休克、抗感染等西医常规治疗,治疗组在西医常规治疗基础上给予口服消炎利胆汤,14d后观察临床疗效,比较丙氨酸转氨酶(ALT)、天冬氨酸氨基转移酶(AST)、胆碱酯酶(CHE)、直接胆红素(D-Bil)与间接胆红素(I-Bil)等肝功能指标,血清白介素-6(IL-6)与白介素-10(IL-10)降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)炎症因子水平,并评价生活质量。结果 14d后,治疗组腹痛缓解时间、体温恢复时间、黄疸减轻时间均短于对照组(P<0.05)。治疗组AST、ALT、D-Bil和I-Bil均低于对照组,但CHE高于对照组(P<0.05)。治疗组血清IL-10高于对照组,IL-6、PCT、TNF-α低于对照组(P<0.05)。治疗组躯体功能、认知功能、社会功能、情绪功能、角色功能评分高于对照组(P<0.05)。结论自拟消炎利胆汤可改善急性梗阻性化脓性胆管炎(肝胆湿热证)患者的临床症状和肝功能指标,减轻炎症反应,提高生活质量。
Objective： To study the influence of self-made Xiaoyan Lidan Decoction on liver function and inflammation factor of patients with acute obstructive suppurative cholangitis. Methods： 94 patients weredivided into the treatment group（47 cases） and the control group（47 cases） according to the computer random number table method. The control group was given conventional Western medicine therapy,and the treatment group was given Xiaoyan Lidan Decoction on the basis of conventional Western medicine treatment. After 14days,the clinical curative effect was observed,and the indices of liver function of alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,cholinesterase（CHE）,direct bilirubin（D-Bil） and indirect bilirubin（I-Bil） were compared,and the levels of serum interleukin-6（IL-6）,interleukin-10（IL-10）,calcitonin original（PCT） and tumor necrosis factor（TNF-α） weredetected,and the quality of life was evaluated. Results： After 14d,the time of abdominal pain remission,temperature recovery and jaundice reducing in the treatment group were lower than those of the control group（P 〈 0.05）. AST,ALT,D-Bil and I-Bil in the treatment group were lower than those of the control group,but CHE in the treatment group was higher than that of the control group（P 〈 0.05）. The level of serum IL-10 was higher than that of the control group,and the levels of IL-6,PCT and TNF-α in the treatment group were lower than those of the control group（P 〈 0.05）. The scores of physical function,cognitive function,social function,emotional function and role function in the treatment group were higher than those of the control group（P 〈 0.05）. Conclusion： Xiaoyan Lidan Decoction on patients with acute obstructive suppurative cholangitis with liver and gallbladderdamp-heat syndrome can improve the liver function index,reduce inflammation,and improve the quality of life.
作者
王楠
赵佳
WANG Nan;ZHAO Jia(Orthopedics Hospital of Shenyang,Liaoning, Shenyang 110044 ,China.)
出处
《中国中医急症》
2018年第4期657-659,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
国家中医药管理局中医药科学技术研究专项课题(2015ZL76)
关键词
急性梗阻性化脓性胆管炎
肝胆湿热
消炎利胆汤
肝功能
炎症因子
Acute obstructive suppurative cholangitis
Liver and gallbladder damp-heat
Xiaoyan Lidan Decoction
Liver function
Inflammatory cytokines
