摘要
本实验观察了发热家兔脑脊液(CSF)和血浆中精氨酸加压素(AVP)含量的变化及禁水对家兔内毒素(ET)发热效应的影响。实验结果表明:1.隔区注射AVP可明显抑制家兔ET性发热效应;2.发热组家兔CSF和血浆中AVP含量较正常组明显降低;3.禁水可明显对抗家兔ET性发热效应,其抗热作用与CSF和血浆中AVP含量升高有关;4.禁水也可使正常家兔体温水平下移。上述实验结果提示,AVP可能是家兔体内一种内源性退热物质,同时在正常体温调节中也可能发挥一定的作用。
The present experiments were carried out in rabbits to determine whether arginine vaso-pressin (AVP) can suppress pyrogen fever, the effect of water deprivation on endotoxin fever and changes of AVP contents in cerebrospinal fluid (CSF) and plasma during fever. The results were as follows: (1) Injection of AVP into the septal area obviously inhibited the endotoxin-induced fever in rabbits. (2) AVP contents in CSF and plasma decreased markedly in febrile rabbit. (3) Water deprivation led to significant reduction of fever in the conscious rabbit and significant increase in AVP contents of CSF and plasma in comparison with those of control animals. (4) AVP contents in CSF and plasma increased markedly and the rectal temperature decreased after water deprivation in normal rabbit. The results indicate that AVP may play the role of endogenous antipyretic in the rabbit brain.
出处
《中国应用生理学杂志》
CAS
CSCD
1991年第2期134-138,共5页
Chinese Journal of Applied Physiology
关键词
发热
精氨酸和压素
禁水
抗热作用
fever
arginine vasopressin (AVP)
septal area
water deprivation
antipyretic effect
