摘要
巨噬细胞诱导的C型凝集素(macrophage-inducible C-type lectin,Mincle)受体是模式识别受体家族的重要成员,可以识别从坏死细胞中释放的自配体,并与下游的脾酪氨酸激酶(Spleen tyrosine kinase,Syk)作用激活单独信号通路,引发一系列炎性反应。越来越多的实验数据表明,Mincle/Syk信号转导通路参与了包含卒中在内的多种神经系统疾病的炎症反应,特异性的抑制该通路激活可以抑制神经炎症,修复神经功能损伤。本文主要对Mincle作用机制和病理研究进展进行综述,并对Mincle对出血性卒中的治疗作用进行展望。
Macrophage-inducible C-type lectin（Mincle） is one of the important members of the family pattern recognition receptors, can identify the release from a dead cells from the ligand, activate downstream of the spleen tyrosine kinase（Syk） signal path alone, and cause a series of inflammatory reaction.More and more studies shows that as the Mincle/Syk signaling pathway participate in the inflammatory response to a variety of neurological diseases including stroke, inhibit the activation of this pathway can prevent nerve inflammation and improve neurological damage. This review is to summarize the essential mechanisms and pathological progress about Mincle/Syk in hemorrhagic stroke and highlight the prospective possibility of applying these approaches in ICH therapy strategy.
作者
刘晓莹
邹伟
于学平
LIU Xiao-Ying1, ZOU Wei2, YU Xue-Ping2.(1.The First Clinical Medical School of Heilongjiang University of Chinese Medicine, Harbin 150040, China; 2.Department of Neurology, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, Chin)
出处
《中国卒中杂志》
2018年第2期189-193,共5页
Chinese Journal of Stroke
基金
国家自然科学基金(81473764
81273824)
黑龙江省自然科学基金重点项目(ZD201204)
教育部博士点基金项目(20102327110003)
