摘要
目的探讨赤道几内亚胎膜早破患者预防感染临床应用抗菌药物情况及其对妊娠结局的影响。方法收集赤道几内亚首都马拉博地区医院的212例胎膜早破患者的临床资料,分析预防感染使用抗菌药物种类,并比较其对母婴临床结局的影响。结果 212例胎膜早破患者预防感染抗菌的药物使用率为83.97%(178/212);主要使用的抗生素类型为青霉素有149例(83.71%)。应用抗生素患者出现早产、新生儿感染、死亡等不良妊娠结局显著低于不使用抗生素者(P<0.01),但使用不同抗生素间的不良妊娠结局及新生儿体征差异无统计学意义(P>0.05)。结论青霉素类抗生素能有效改善该地区胎膜早破患者临床结局,但应关注其过敏反应。
Objective To investigate the clinical application of antimicrobial agents in the patients with premature rupture of membranes（PROM） in Equatorial Guinea and the effect on pregnancy outcome. Methods The clinical data of 212 PROM patients were collected in Malabo Area Hospital of Equatorial Guinea from August 2014 to April 2016 to analyze the types of antibiotics used to prevent infections and compare their effect on the clinical outcomes of pregnant patients and their infants.Results The application rate of antibiotics in the 212 PROM patients was around 84%; the main antibiotics used was penicillins（149 cases, 83.71%）. The patients medicated with antibiotics was significantly lower than those medicated with no antibiotics in terms of the incidence of adverse pregnancy outcomes such as premature delivery, neonatal infection and death（P〈0.01）. However, there was no statistical difference in the adverse pregnancy outcomes and the signs of infants among different antibiotics（P〈0.05）. Conclusion Penicillin can effectively improve the clinical outcome of the PROM patients in this area, but the hypersensitivity must be paid attention.
作者
廖靖
钟巨斌
程玉瑜
LIAO Jing;ZHONG Ju-bing;CHENG Yu-yu(Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China;The second Affiliated Hospital of Guangdong Medical University, Zhanjiang 524003, China)
出处
《广东医科大学学报》
2017年第6期667-670,共4页
Journal of Guangdong Medical University
基金
广东省医学科学技术研究基金项目(No.A2015353)
关键词
胎膜早破
感染
抗生素
青霉素
premature rupture of membranes
infection
antibiotics
penicillins
