摘要
目的观察持续血液净化对脓毒症患儿血流动力学及炎症因子的影响。方法 66例脓毒症患儿随机分为对照组和观察组,分别给予常规治疗、常规治疗+持续血液净化,比较两组的治愈率、血流动力学、多巴胺、尿量、血乳酸、炎症因子(IL-1、IL-6、IL-8、TNF-α)水平。结果观察组、对照组治愈率分别为90.9%、69.7%,差异有统计学意义(P<0.05)。观察组血流动力学指标及多巴胺、尿量、乳酸、炎症因子水平改善均显著优于对照组(P<0.01)。结论脓毒症患儿在常规治疗基础上加用持续血液净化,可显著提高治愈率、改善血流动力学及炎症因子水平。
Objective To investigate the effect of continuous blood purification（CBP） on hemodynamics and inflammatory cytokines in septic children. Methods Sixty-six septic children were randomized to control and observation groups, and received conventional treatment and conventional treatment plus CBP, respectively. The cure rate, hemodynamics,dopamine, urine volume, blood lactic acid, and inflammatory cytokines（IL-1, IL-6, IL-8 and TNF-a） were compared between two groups. Results The cure rate was higher in observation group than in control group（90.9% vs. 69.7%,P〈0.05）.Moreover, hemodynamic parameters, dopamine, urine volume, and levels of lactic acid and inflammatory cytokines were better in observation group compared with control group（P〈0.01）. Conclusion The conventional treatment plus CBP can improve the effective rate, hemodynamics and inflammatory cytokines in septic children.
作者
莫庆仪
黄晓雯
付四毛
周涛
MO Qing-Yi;HUANG Xiao-Wen;FU Si-Mao;ZHOU Tao(Pediatric Intensive Care Unit, Zhongshan Boai Hospital, Zhongshan 528403, Chin)
出处
《广东医科大学学报》
2017年第6期654-657,共4页
Journal of Guangdong Medical University
