摘要
衰老相关分泌表型(SASP)是指衰老细胞出现的分泌功能增强,其分泌的多种细胞因子在体内发挥重要调节作用。在不同刺激引起的细胞衰老模型中,SASP普遍存在且种类繁多,主要包含生长因子、趋化因子、促炎细胞因子、胞外蛋白酶和不可溶蛋白等。SASP在体内作用取决于所处环境,可对机体产生有益或有害影响。SASP一方面可促进胚胎发育及组织修复,招募并激活免疫细胞,抑制肿瘤发展;另一方面可引起慢性炎症,促进肿瘤生长、侵袭。该文总结了SASP生物学作用及发生机制的研究进展。
Senescence-associated secretory phenotype（SASP） refers to the enhanced secretory function of senescent cells, which plays important regulatory roles in a variety of biological processes. In different models of cell senescence caused by various stimuli, SASP is generally present and mainly include growth factors, chemokines, proinflammatory cytokines,extracellular proteases and insoluble proteins. The in vivo role of SASP is dependent on the environment, and it may exert beneficial or deleterious effects. On the one hand, SASP can promote embryonic development and tissue repair, facilitate the recruitment and activation of immune cells, and inhibit tumor development. On the other hand, SASP can lead to chronic inflammation and promote tumor growth and invasion. That paper summarizes the advances on biological roles and occurrence mechanisms of SASP.
作者
张明萌
廖小欣
李晓毅
杨杰
石本艳
饶敏腊
刘新光
孙雪荣
ZHANG Ming-Meng;LIAO Xiao-Xin;LI Xiao-Yi;YANG Jie;SHI Ben-Yan;RAO Min-La;LIU Xin-Guang;SUN Xue-Rong(Institute of Aging Research, Dongguan Scientific Research Center;The Second Clinical School;School of Laboratory Medicine;Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics;Guangdong Medical University, Dongguan 523808, China;5. Institute of Biochemistry ＆ Molecular Biology, Guangdong Medical University, Zhanjiang 524023, Chin)
出处
《广东医科大学学报》
2017年第6期569-575,共7页
Journal of Guangdong Medical University
基金
国家自然科学基金(No.81370456)
东莞市社会科技发展项目(No.2014108101047)
广东医科大学重点培育基金(No.Z2016004)
广东大学生科技创新培育专项资金(No.pdjh2017b0226)
大学生创新创业训练计划项目(No.201610571013,201710571030)
关键词
细胞衰老
衰老相关分泌表型
DNA损伤
cellular senescence
senescence-associated secretory phenotype
DNA damage
