摘要
目的探讨事件相关电位P300与抑郁症严重程度之间的关系。方法对28例中度抑郁症患者、41例重度抑郁患者与70例健康对照的P300行对照研究。结果抑郁症患者P3潜伏期与HAMD评分呈正相关（r=-0．514，P〈0．01）；中、重度抑郁组较健康对照组N2、P3潜伏期延长，P3波幅降低，差异均有统计学意义（P〈0．05）；重度抑郁组较中度抑郁组P3潜伏期延长，差异有统计学意义（P=0．017）。结论抑郁症的认知功能损害与严重程度有关，P3潜伏期可能是抑郁症严重程度的预测性指标。
Objective To explore the relationship between event-related potentials P300 and the severity of depression. Methods A control study was conducted among 28 moderate depression patients, 41 severe depression patients and 70 healthy controls. Results The latency of P3 was positively correlated with the scores of Hamilton Depression Scale （HAMD-17）（r=0.514, P 〈 0.01）. Compared with the healthy control group, the moderate group and severe group showed prolonged latencies of N2 and P3, and decreased P3 amplitude, with statistical significance （P 〈 0.05）. Compared with moderate group, the severe group showed prolonged P3 latency （P=0.017）. Conclusions The cognitive impairment might be associated with the severity of the depression, and the P3 latency might be used as an indicator of severity in depression.
作者
张振清
张晓阳
吴娓娓
ZHANG Zhen-qing,ZHANG Xiao-yang, WU Wei-wei.(Department of Psychology, Xiamen Xianyue Hospital, Xiamen 361012, Chin)
出处
《神经疾病与精神卫生》
2017年第12期876-878,共3页
Journal of Neuroscience and Mental Health
基金
厦门市科学技术局科技计划项目（3502220154062）
福建省卫生计生委青年科研课题（2015-2-53）
关键词
抑郁症
认知
事件相关电位
严重程度
Depression
Cognition
Event-related potentials
Severity
