摘要
本实验用萤光偏振免疫分析仪(TDX)测定茶碱血药浓度。对8名老年慢性阻塞性肺病(COPD)患者进行了氨茶碱口服多剂量给药的药物动力学研究。血药浓度数据在IBM—PC计算机上用PKBP-Ni程序处理,得到老年COPD患者的茶碱药物动力学参数,房室模型以一拟合。消除速率常数(Ke)为0.0555±0.0111h^(-1),消除半衰期(T1/2)为13.01±2.98h,表观分布容积(Vd)为29.42±6.80L,清除率(CL)为1.61±0.37L/h,曲线下面积(AUC)为131.3±33.8hmg/L。本实验得到的COPD老人茶碱的T1/2比文献报道的健康老人的T1/2有明显延长,CL有所下降。
Pharmacokinetics parameter of theophylline were studied in 3 elderly COPDpatients after multiple dosing. Plasma concentration was analysed by TDX.After calculation with one-compartment model, the elimination rate constant(Ke)was 0.0555±0.0111 h^(-1), the elimination half-life (T1/2) was 13.01±2.98h, the app-arent volume of distributibn (Vd) was 29.42±6.89L, the clearance (CL) was1.61±0.37 L/h. and the Area Under Curve (AUC) was 131.3±33.8h·mg/L. Thatthe T1/2 of eldetly COPD obtained from this experiment was compared with T1/2of normal elderly men from published reports has increased obviously, CL wasdecreased.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1991年第7期294-295,共2页
Chinese Journal of Hospital Pharmacy
