摘要
【目的】探讨全麻复合硬膜外麻醉对子痫前期患者凝血功能相关指标的影响。【方法160例子痫前期患者，随机分为两组，各30例，对照组在剖宫产术前给予全身麻醉，观察组实施全麻复合硬膜外麻醉，比较两组麻醉前（T0）、麻醉平稳后（T1）、术中30min（T2）、术后24h（T3）的平均动脉压（MAP）、心率（HR）、血氧饱和度（Sp02）及各时点活化部分凝血酶原时间（APTT）、凝血酶原时间（PT）、纤维蛋白原（FIB）、D-二聚体（D-D），并观察并发症发生情况。【结果】观察组麻醉诱导时间短于对照组，麻黄碱用量多于对照组（P〈O．05）；观察组T1、T2、T3时MAP、HR低于，T1、T2时spO2高于对照组（P〈0．05）；观察组T1、T2、T3时APTT长于对照组，FIB、D-D水平低于对照组，两组各时点PT对比差异无显著性（P〈0．05）；观察组麻醉相关并发症发生率低于对照组（P〈0．05）。【结论】全麻复合硬膜外麻醉对子痫前期患者凝血功能、血流动力学指标，可缩短麻醉诱导时间，减少相关并发症，值得在临床推广应用。
[Objective]To explore the effects of general anesthesia combined with epidural anesthesia on coagulation function in preeclampsia patients. [Methods]A total of 60 preeclampsia patients were divided into two group, with 30 cases in each group. The control group was given general anesthesia before cesarean sec- tion, and the observation group was treated with general anesthesia combined with epidural anesthesia. The levels of MAP, HR, SpOz and APTT （activated partial prothrombin time）, PT （prothrombin time）, FIB （fi- brinogen） and D-D （D-dimer） at the time before anesthesia （T0）, after anesthesia was stable （T1）, intraoper- ative 30min （T2）, postoperative 24h （T3） were compared between the two groups. The complications were observed as well. [Results] The anesthesia induction time in the observation group was shorter and the ephed- rine dosage was more than that of the control group （ P 〈0.05）, The levels of MAP and HR at the time point of T1, T2 and T3 were lower, and the level of SpO2 at the time point of T1 and T2 were higher in the observa- tion group than those in the control group （ P 〈0.05）. The APTT was longer in the observation group than in the control group at the time point of T1, T2 and T3, and the levels of FIB and D-D were lower in the observa- tion group than in the control group. There was no significant difference in the PT at each time point in the two groups （ P 〈0.05）. The incidence rate of complications related to anesthesia in the observation group was low- er than that in the control group. [Conclusion] General anesthesia combined with epidural anesthesia has little influence on blood coagulation function, hemodynamic index in preeclampsia patients. It can shorten the anes- thesia induction time and reduce related complications. Therefore it is worthy of clinical application.
作者
李俊芳
郭小群
LI fun-fang ,GUO Xiao-qun(Pujiang County People＇s Hospital, Pujiang, Sichuan Province 61163)
出处
《医学临床研究》
CAS
2018年第3期507-509,共3页
Journal of Clinical Research
关键词
麻醉
全身
麻醉
硬膜外
先兆子痫
血液凝固
血流动力学
Anesthesia, General
Anesthesia, Epidural
Pre-Eclampsia
Blood Coagulation
Hemodvnamics
