摘要
简介氟哌酸灌肠剂的制备和质量控制。通过临床观察得出,本品保留灌肠治疗菌痢优于口服氟哌酸(P<0.05)。且局部用于皮肤浅表化脓性感染也初获佳效。
A new dosage form of norfloxacin and its rectal administration have beendeveloped, the new form was named AM-715 enema. forty cases of bacillarydysentery were divided into two groups (oral group and rectal group, 20 each).for oral group 200mg AM-715 tablet (or capsule) was given t.i.d.; for rectalgroup 20-30 ml AM-715 enema (retention) qd (or bid for advanced cases). thoughboth the two groups were cured, the rectal group took ashorter time to clear upclinical signs and to restore a normal stool routine than the based on the differe-nce of two days. oral group (p<0.05), showing the rectal use (enema) is superiorto the oral (tablet or capsule) administration for treating bacillary dysentery.AM-715 enema has many advantages-less dosage, less adverse effect, rapid acting,and a short course. in addition, a paint (inunctum) of AM-715 has good effecton skin superficial pyogenic infections.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1991年第7期328-329,共2页
Chinese Journal of Hospital Pharmacy
关键词
氟哌酸
灌肠剂
痢疾
细菌性
Norfloxacin (AM-715)enema
bacillary dysentery
skin superfical pyogenic infections
