摘要
目的对比头部运动区注射鼠神经生长因子治疗痉挛性脑瘫的临床疗效及安全性。方法纳入2013-06—2017-06就诊于菏泽市立医院儿科6个月~6岁的痉挛性脑瘫患儿150例,随机分为实验组和治疗组,所有患儿接受运动及综合康复治疗。实验组在对照组基础上进行鼠神经生长因子18μg头部运动区注射,1次/d,10次为1个疗程,共进行3个疗程,每个疗程间隔10 d。观察2组粗大运动功能量表(GMFM-88)评分情况。结果所有患者3个疗程后GMFM-88评分较治疗前显著提高,差异有统计学意义(P<0.05);实验组3个疗程后GMFM-88评分显著高于对照组,差异有统计学意义(P<0.05);实验组治疗后6个月~3岁患儿评分与>3~6岁患儿比较差异无统计学意义(P>0.05)。结论鼠神经生长因子可有效改善6个月~6岁痉挛型脑瘫患儿的运动功能,值得临床推广。
Objective To compare the efficacy and safety of injection of mouse nerve growth factor into the motor area of the head in the treatment of motor function in children with spastic cerebral palsy. Methods This study included 150 spastic cerebral palsy children aged between 6 months and 6 years old, which were treated between June 2013 and June 2017 in Department of Pediatrics, Heze Municiple Hospital. All subjects were randomly divided into experimental group and control group as 1：1 pairedcase control study,all patients received comprehensive rehabilitation treatment and exercise. Children in experimental group were given additional nerve growth factor 18μg injected in head exercise area on the basis of the control group for 3 courses, once a day, 10 times for 1 course,each course had interval of 10 days. The gross motor function scale（GMFM-88）scores of two groups were observed and compared. Results After 3 courses,the scores of GMFM-88 were significantly higher than those before treatment, and the difference was statistically significant （P〈0. 05）. After 3 courses, the GMFM-88 score was significantly higher than that in the control group,and the difference between the two groups was statistically significant （P〈0. 05）. The GMFM-88 scores of children between 6 months to 3 years old and 3 to 6 years old children were statistically significant（P〉0.05）. Conclusion The mouse nerve growth factor can effectively treat the motor function of children with spastic cerebral palsy from 6 months to 6 years old, the curative effect is remarkable and it is worthy of clinical application.
作者
王蕾
李燕梅
WANG Lei ,LI Yanmei(Department of Pediatrics, Heze Municiple Hospital, Heze 274000, China)
出处
《中国实用神经疾病杂志》
2018年第4期365-368,共4页
Chinese Journal of Practical Nervous Diseases
基金
国家自然科学基金面上项目(81070276)
