摘要
人口老龄化是一个不可忽视的社会问题。随着老龄化的日益加剧,神经系统疾病(诸如帕金森病、阿尔兹海默症、中风等老年性疾病)的发病率也逐年上升。药用植物迷迭香中主要的二萜类化合物——鼠尾草酸在神经保护方面具有重要作用,为预防和治疗神经系统疾病提供了希望和更多选择。本文综述了鼠尾草酸的神经保护作用,按照疾病类型探讨了鼠尾草酸对神经系统疾病的预防治疗机制,有助于理清鼠尾草酸的神经药理作用。
Population ageing is a severe social problem. The incidence of nervous system diseases（such as Parkinson＇s disease, Alzheimer＇s, stroke, etc.） is increasing year by year. Carnosic acid, one of the major diterpenes found in medicinal plant rosemary, is with important neuroprotective effects and presents hopes and more options for preventing or treating nervous system diseases. This review has summarized the neuroprotective effects of carnosic acid. And the mechanisms of carnosic acid in preventing and treating nervous system diseases were discussed according to disease categories, which will help us to further understand the neuropharmacological effects of carnosic acid.
作者
李艳
谭新敏
罗成
LI Yan, TAN Xinmin, LUO Cheng(School of Medicine, Yichun University, Yichun 336000, Chin)
出处
《生命的化学》
CAS
CSCD
2018年第1期91-96,共6页
Chemistry of Life
基金
国家自然科学基金项目(81560584)
江西省自然科学基金项目(20161BAB215196)
江西省教育厅科学技术资助项目(GJJ151021)
关键词
鼠尾草酸
帕金森病
阿尔兹海默症
脑损伤
炎症
camosic acid
Parkinson disease
Alzheimer＇s disease
brain damage
inflammatory
