摘要
目的:探讨逐瘀散结汤联合米司非酮治疗子宫肌瘤的临床疗效及对血清心肌素、核因子(NF)-κB p65、血管内皮生长因子(VEGF)水平的影响。方法:选择2014年11月至2016年11月我院接诊的94例子宫肌瘤患者,通过随机数表法分为观察组(n=47)和对照组(n=47),对照组给予米非司酮口服治疗,观察组联合逐瘀散结汤治疗,均连续治疗3个月。比较两组治疗前后血清心肌素、NF-κB p65、VEGF、子宫体积、子宫肿瘤体积及孕酮(P)、促卵泡素(FSH)、促黄体生成素(LH)、雌二醇(E2)水平的变化、临床疗效及不良反应的发生情况。结果:治疗后,两组血清心肌素水平均较治疗前明显升高(P<0.05),而血清NF-κB p65、VEGF、子宫体积、子宫肿瘤体积及P、FSH、LH、E2均较治疗前显著降低(P<0.05);而观察组血清心肌素水平明显高于对照组(P<0.05),子宫体积、子宫肿瘤体积、血清NF-κB p65、VEGF、P、FSH、LH、E2水平均明显低于对照组(P<0.05)。治疗后,观察组临床疗效总有效率明显高于对照组,但不良反应总发生率明显低于对照组(P<0.05)。结论:逐瘀散结汤联合米非司酮治疗子宫肌瘤的临床效果显著优于米非司酮单药治疗,其可有效缩小子宫和子宫肌瘤体积,改善性激素表达,可能与显著提高血清心肌素水平并降低血清NF-κB p65及VEGF的表达有关。
Objective： To study the curative efficacy of Zhuyu Sanjie Decoction combined with mifepristone in the treatment of hysteromyoma and its effects on the serum myocardin, nuclear factor（NF）-κB p65 and vascular endothelial growth factor（VEGF） levels.Methods： 94 cases of patients with hysteromyoma who were treated from November 2014 to November 2016 in our hospital were selected. According to random number table, those patients were divided into the observation group（n=42） and the control group（n=48）.The control group was treated with oral mifepristone, while the observation group was treated with Zhuyu Sanjie Decoction. The changes of myocardial, NF-κB p65, VEGF, uterus volume, hysteromyoma volume, serum progesterone（P）, follicle stimulating hormone（FSH）,luteinizing hormone（LH） and estradiol（E2） levels before and after treatment, the clinical efficacy and adverse reaction were compared between the two groups. Results： After treatment, the serum myocardial hormone levels of the two groups were significantly higher than those before treatment（P〈0.05）; and the serum NF-κB p65, VEGF, uterus volume, hysteromyoma volume, P, FSH, LH and E2 levels were significantly lower than those before treatment（P〈0.05）; the level of serum myocardial hormone in the observation group was significantly higher than that of the control group（P〈0.05）; the uterus volume, hysteromyoma volume, serum NF-κB p65, VEGF, P,FSH, LH and E2 were significantly lower than those of the control group（P〈0.05）. After treatment, the total effective rate in the observation group was significantly higher than that of the control group, but the total incidence of adverse reactions was significantly lower than that of the control group（P〈0.05）. Conclusion： The clinical effect of Zhuyu Sanjie decoction combined with mifepristone in the treatment of uterine fibroids was better than that of mifepristone monotherapy, which could effectively reduce the volume of uterus and uterine fibroids, and improve the expression of sex hormones, it may be related to significantly increasing serum myocardial hormone level and decreasing expression of serum NF-κB p65 and VEGF.
出处
《现代生物医学进展》
CAS
2017年第36期7116-7119,共4页
Progress in Modern Biomedicine
基金
陕西省自然科学基金项目(201012473)
