摘要
目的 鉴于左乙拉西坦在各种啮齿类动物上的抗癫痫作用不同 ,未见报告其在自发性癫痫大鼠上的作用 ,故研究之。方法 在大脑海马和皮质部位安置电极 ,观察腹腔注射单剂量左乙拉西坦对自发性癫痫大鼠脑电图的影响。结果 给左乙拉西坦(40 ,80和 16 0mg·kg- 1,ip)后 135～ 16 5min ,癫痫小发作的总持续时间分别下降到给药前水平的 (87±15 ) % ,(34± 7) %和 (39± 19) %。大发作的总持续时间下降到 (81± 2 8) % ,(6 5± 11) %和 (5 2± 7) %。大发作的出现频率下降到 (71± 2 9) % ,(5 4± 12 ) %和 (32± 15 ) %。
AIM In view of the difference of the effects of levetiracetam (Lev) in different rodent models and there is no report on its effects in spontaneously epileptic rats (SER), the effects were studied. METHODS Electrocorticogram and depth electroencephalographic activity in hippocampus of SER were recorded with implanted electrodes after acute intraperitoneally administration of Lev. RESULTS The total duration of absence-like seizures was significantly reduced from 100% to (87±15)%, (34±7)% and (39±19)% by single dose Lev (40, 80 and 160 mg·kg -1, ip), respectively, at 135-165 min after administration. The frequency of tonic convulsion was reduced from 100% to (71±29)%, (54±12)% and (32±15)%. The total duration of tonic convulsion was also reduced to (81±28)%, (65±11)% and (52±7)%, respectively. CONCLUSION Lev is effective for treatment of absence-like seizures and tonic convulsion on SER.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2002年第4期241-245,共5页
Chinese Journal of Pharmacology and Toxicology
关键词
左乙拉西坦
大鼠
自发性癫痫
脑电图
海马
levetiracetam
epilepsy
rats, spontaneously epileptic
hippocampus
electroencephalography
