摘要
本文对832例患者(分别使用六种药物)的耳垂血标本进行了血药浓度监测,揭示了临床用药中存生的不合理性。采用末端相取点法和两步法估算了六种药物的个体、群体、不同性别,不同年龄组的消除速率常数(K),其中50～56岁分别与14～49岁和60岁以上年龄组间的庆大霉素K值有极显著差异(P<0.01);并向临床医生推荐了新的给药方案。
The unreasonable administration in clinic was shown by monitoring bloodlevel of 6 drugs in earlobe of 832 patients. The elimination rete constants(k) ofdrugs for individual. population, sex and several ageranges were calculated by themethod of taking blood sample in terminal phase and two-stage method. The K ofgentamycin of 50～59 years-range was different significantly to that ranges of14～49 and over 60 years(P<0.01). The adjusted administration schedule was propo-sed to doctors.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1991年第3期104-106,共3页
Chinese Journal of Hospital Pharmacy
关键词
药物监测
血药浓度
elimination rate constart
administration schedule
antibiotics
digoxin
