摘要
目的观察与探究胺碘酮联合肾素-血管紧张素系统(RAS)抑制剂治疗高血压合并阵发性房颤的临床效果。方法选取2013年11月至2016年11月于本院就诊及治疗的40例高血压合并阵发性房颤患者作为研究对象,按照随机数字表法将其分为对照组和观察组,每组20例。对照组患者给予胺碘酮治疗,观察组患者给予胺碘酮联合RAS抑制剂治疗,对比两组患者的临床效果。结果观察组患者的治疗总有效率(95.00%)与对照组患者(70.00%)比较,差异有统计学意义(P<0.05)。治疗后,两组患者的舒张压、收缩压水平及左心房内径均降低,与治疗前比较差异有统计学意义(P<0.05);观察组患者的舒张压、收缩压水平分别为(76.14±4.10)、(126.58±5.04)mm Hg,与对照组患者的(79.18±5.01)、(135.60±4.72)mm Hg比较,差异有统计学意义(P<0.05);观察组患者的左心房内径为(33.01±3.04)mm,与对照组患者的(35.16±3.15)mm比较,差异显著(P<0.05)。结论对高血压合并阵发性房颤患者使用胺碘酮联合RAS抑制剂治疗的临床效果较好。
Objective To observe and explore the clinical effect of amiodarone combined with renin angiotensin system（RAS） inhibitors in the treatment of hypertension complicated with paroxysmal atrial fibrillation. Methods Forty cases of hypertension complicated with paroxysmal atrial fibrillation diagnozed and treated from November 2013 to November 2016 in our hospital were selected as the research objects, and divided into control group and observation group according to random number table method, with 20 cases in each group. Amiodarone therapy was used in the control group, and amiodarone combined with RAS inhibitors were used in the observation group, the clinical effects between the two groups were compared. Results The total effective rate in the observation group（95.00%） was significantly higher than that in the control group（70.00%）（P0.05）. After treatment, the levels of diastolic blood pressure, systolic blood pressure and left atrial diameter significantly decreased in both groups（P0.05）. The levels of diastolic blood pressure and systolic blood pressure in the observation group were（76.14 ±4.10） and（126.58 ±5.04） mm Hg respectively, which were significantly lower than（79.18±5.01） and（135.60±4.72） mm Hg in the control group（P0.05）. The diameter of the left atrium in the observation group was（33.01±3.04） mm, which was significantly different from（35.16 ±3.15） mm in the control group（P0.05）. Conclusion The clinical effect of amiodarone combined with RAS inhibitors therapy is good in the treatment of patients with hypertension complicated with paroxysmal atrial fibrillation.
出处
《临床医学研究与实践》
2018年第5期32-33,共2页
Clinical Research and Practice
