摘要
目的 为了研究颈椎小关节滑膜的病理学改变与颈椎病的关系 ;方法 经采用常规病理学方法、免疫组化、免疫荧光以及乙醛酸诱发生物单胺递质荧光研究了颈椎小关节滑膜的病理学表现 ;结果 总结了颈椎病的形态学特点。临床表现特点主要是头晕、四肢的感觉运动障碍以及交感和副交感等自主神经系统的紊乱。颈椎病的病理学特点主要是粒细胞、淋巴细胞和巨噬细胞等炎细胞浸润、滑膜因为纤维增生和脂肪化而增厚 ,血管增生、血管炎和滑膜周围肌组织的变性。通过免疫组化、免疫荧光、乙醛酸诱发生物单胺递质荧光的方法我们发现颈椎及其周围组织中存在神经肽 Y物质和对乙醛酸起反应的单胺类物质 ,推测为交感神经。还存在以降钙素基因相关肽为标志的痛觉神经。同时也存在炎症因子 ,如 Ig G和 C3 ;结论 以上研究结果说明颈椎小关节滑膜中存在交感神经和少量痛觉神经 。
Objective In order to study relevance of the pathological morphology of synovialis of facet joint of cervical spine to cervical spondylopathy. Methods We resort to routine pathologic methodology, immunohistochemistry,immunofluorescence and ethylaldehyde acid-induced biomonoaminic fluorescence. Results The authors discover that the pathologic morphology of cervical spondylopathy is mainly inflammation, thickening of synovialis through fibrosis and adiposation, exudation of fibrin, mucous degeneration, infiltration of lymphocytes, macrophages, and neutrocytes, hyperplasia and inflammation of vessels and degeneration of musculature adjacent to the synovialis. Through immunohistochemistry, immunofluorescence and ethylaldehyde acid-induced biomonoaminic fluorescence, we discovered neuropeptide Y-positive fibers, ethylaldehyde acid reactive fibers and calcitonin gene-related peptide-positive fibers that suggest the existence of sympathetic fibers as well as nociceptive fibers in the synovialis of cervical spine. At the same time, some inflammatory factors such as IgG and C 3 are found in the synovialis of cervical spine. Conclusion Through the authors' work, the existence of sympathetic fibers, some nociceptive fibers and inflammation in the synovialis of facet joints of cervical spine are corroborated.
出处
《颈腰痛杂志》
2002年第3期177-180,266,共5页
The Journal of Cervicodynia and Lumbodynia
关键词
颈椎小关节滑膜
病理学
颈椎病
发病
交感神经
痛觉神经
cervical spondylopathy
pathology
sympathetic fibers
nociceptive fibers
inflammation
