摘要
目的 :研究肾移植术前 HL A系统检测方法预防超急排斥反应 (简称超排 )的作用。方法 :115 2例肾移植中有 5 5 0例单纯行淋巴细胞毒抗体试验 (简称淋巴毒 ) ,335例行淋巴毒试验和 HL A血清学分型 ,在此基础上有 2 6 7例增加 PRA检测 ,观察每组超排发生率的变化。 结果 :淋巴毒值≤ 10 %和供受者 HL A相同位点≥ 3时 ,超排发生率与淋巴毒值和 HL A相同位点数无关。与单纯行淋巴毒试验比 ,肾移植术前 HL A血清学分型能明显减少肾移植超排发生率 ,增加 PRA辅助检测后肾移植超排发生率进一步下降。 结论 :在淋巴毒试验基础上 ,HL A配型结合
Objective:To investigate the effect of 3 HLA matching measures on preventing hyperacute rejection(HAR). Methods:Among 1 152 cases,550 cases received anti donor lymphocytotoxic crossmatch(LXM),335 cases received LXM and HLA serological test,267 cases of the latter again received panel reaction antibody(PRA)test, the change of the HAR rate with different HLA matching measures were analyzed. Results:If LXM value ≤10% or HLA matched loci ≥3,the rate of HAR was unrelated to LXM value or HLA matched loci. HAR rate decreased significantly in patients with LXM and HLA serological test, and decreased more markedly in those with additional PRA test compared with those only with LXM test. Conclusion:HLA test and PRA are necessary and effective to avoid HAR.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2002年第8期886-888,共3页
Academic Journal of Second Military Medical University
关键词
HLA系统
检测
预防
肾移植
超急排斥反应
临床研究
hyperacute rejection
lymphocytotoxic crossmatch
HLA antigens
panel reaction antibody
kidney transplantation
