摘要
目的 :探讨氯沙坦对球囊成形术后兔血管内膜增殖的影响。方法 :将 2 4只新西兰兔随机分为三组 :对照组、模型组及氯沙坦组。后两组持续给予 1.5 %高胆固醇喂养 ,实验初始行腹主动脉内膜剥脱术 ,8周后对狭窄部位行球囊成形术 ,氯沙坦组于球囊成形术前 1周开始口服氯沙坦 10 m g/ (kg· d)。 12周末取腹主动脉行病理形态学观察。结果 :氯沙坦组内膜厚度 (IT)减少 6 5 % ,内膜面积 (IA )减少 34% ,内膜厚度比中膜厚度 (IT/ MT)减少 32 % ,内膜面积比中膜面积 (IA/ MA)减少 2 8% (P<0 .0 1)。结论
Objective:To investigate the effects of losartan on the neointimal proliferation after balloon angioplasty in rabbits.Methods:Twenty four rabbits were divided randomly into three groups at random:control group,model group and losartan group.The latter two groups were fed with 1.5 % cholesterol diet for 12 weeks.At first the celiac arterial endothelium were denuded.Then they were underwent balloon angioplasty in the celiac artery after 8 weeks.From 1 week before balloon angioplasty losartan group were supplemented by losartan 10 mg/(kg·d).Then the arteries were harvested for morphological observation.Results:Treatment with losartan significantly reduced neointimal thickness(IT) reduce to 65 %,neointimal area(IA) reduce to 34 %,IT/MT reduce to 32 %,IA/MA reduce to 28 %( P <0.01).Conclusion:The therapy of losartan could reduce the neointimal proliferation induced by balloon injury in rabbits without effects on the serrum triglyceride and total cholesterol.
出处
《临床医药实践》
2002年第8期570-572,共3页
Proceeding of Clinical Medicine
关键词
氯沙坦
兔
血管成形术
内膜增殖
losartan
rabbit
angioplasty
neointimal proliferation
