摘要
目的 :探讨抗纤维治疗对不同程度的慢性心力衰竭 (CHF )患者的血清纤维化标志物 : 型前胶原 (PC )、透明质酸 (HA)和层粘蛋白 (L N)的影响。方法 :用放免法测定 41例 CHF患者血清 PC ,HA,LN的含量 ,比较不同程度 CHF患者之间的差异 ,同时行抗纤维化治疗 6～ 8周 ,检测治疗前后变化。结果 :心功能 , 级患者的血清PC ,HA,L N水平显著高于心功能 级的患者 (P<0 .0 1) ;经抗纤维化治疗 ,血清 PC ,HA,L N水平显著下降(P<0 .0 1) ,心功能明显改善。结论 :血清 PC ,HA,LN参与了 CHF的心肌纤维化 ;心肌纤维化随 CHF的严重程度而加重 ;抗纤维化治疗 ,能减缓
AIM:To assess the changes of serum procollagon type PCⅢ,hyaluronic acid(HA) and laminin (LN) in patients with congestive heart failure(CHF) and to investigate the effect of antifibrosis therapy on the above mentioned three serum fibrotic markers. METHODS:Above mentioned three serum fibrotic markers were measured by specific radioimmunoassay and compared for the difference in 41 patients with varied degrees of CHF. All the patients with 2~3 scale of heart function were treated by antifibrosis. After 6~8 weeks therapy,all of the serum fibrotic markers were measured again.RESULTS:The levels of PCⅢ,HA and LN with 3~4 scale heart function were significantly higher than those with 2 scale heart function ( P <0.05, P <0.01). After the antifibrosis therapy,the levels of serum PCⅢ,HA and LN significantly dropped( P <0.01). CONCLUSION:Serum PCⅢ,HA and LN might be involved myocardial fibrosis of CHF. As CHF progressed,the myocardial fibrosis became more servere. Antifibrosis therapy could improve the prognosis of the patients with CHF.
出处
《心脏杂志》
CAS
2002年第4期316-317,共2页
Chinese Heart Journal
