摘要
目的探讨JAK2/STAT3信号通路相关蛋白磷酸化的JAK2(p-JAK2)在食管鳞状细胞癌(ESCC)组织中的表达及意义。方法采用免疫组织化学SP法检测食管鳞癌组织及对应癌旁组织中p-JAK2蛋白的表达。结果食管鳞状细胞癌组织p-JAK2阳性表达率明显高于癌旁正常组织,差异有统计学意义(P<0.05)。p-JAK2表达与肿瘤分化程度相关,差异有统计学意义(P<0.05);而与性别、年龄、病理形态、浸润深度、淋巴结转移及临床分期无明显相关性,差异无统计学意义(P>0.05)。结论在食管鳞状细胞癌组织中p-JAK2的高表达与分化程度呈正相关,与肿瘤恶性程度呈负相关,可能为食管癌的预后判断提供新思路。
Objective To investigate the expression and significance of JAK2/STAT3 signaling pathway related protein p-JAK2 in esophageal squamous cell carcinoma(ESCC).Methods Immunohistochemical SP method was used to detect the expression of p-JAK2 in esophageal squamous cell carcinoma tissues and corresponding adjacent tissues.Results The positive rate of p-JAK2 in esophageal squamous cell carcinoma tissues was significantly higher than that in adjacent normal tissues,and the difference was statistically significant(P <0.05).The infiltration of p-JAK2 was significantly correlated with the degree of tumor differentiation(P <0.05),but not with the gender,age,pathology,depth of invasion,lymph node metastasis and clinical stage(P >0.05).Conclusion The high expression of p-JAK2 in esophageal squamous cell carcinoma is positively correlated with the degree of differentiation and negatively correlated with the degree of malignancy,which may provide new ideas for the prognosis of esophageal cancer.
出处
《新疆医科大学学报》
CAS
2018年第3期281-283,287,共4页
Journal of Xinjiang Medical University
基金
国家自然科学基金(U1603284)
