摘要
目的：探讨真武汤治疗脾肾阳虚型肾衰竭患者对血清瘦素、脂联素的影响。方法：选取自2014年8月—2016年9月收治的符合纳入标准的肾衰竭（脾肾阳虚型）患者72例,按随机数字表法分为对照组36例和观察组36例,对照组采用降压、降糖及控制感染治疗,观察组在降压、降糖及控制感染治疗上采用真武汤加减治疗,连续治疗3周为1个疗程,共2个疗程,治疗前后采肘静脉血测定血清瘦素、脂联素、肾功能、MDA、SOD、GSH-Px等表达水平,同时对比临床疗效及不良反应状况。结果：对照组有效率72.22%（26/36）低于观察组有效率91.66%（33/36）,（P〈0.05）;与治疗前比较,两组治疗后血清Leptin、脂联素表达水平降低,治疗后血清Scr、BUN、UA水平降低,Ccr升高,治疗后血清MDA表达水平降低,血清SOD、GSH-Px表达水平升高（P〈0.05）;与对照组比较,观察组治疗后血清Leptin、脂联素表达水平较低,治疗后血清Scr、BUN、UA水平较低,Ccr较高,治疗后血清MDA表达水平较低,血清SOD、GSH-Px表达水平较高（P〈0.05）。结论：真武汤对于肾衰竭（脾肾阳虚型）患者疗效确切,显著提高肾功能,与降低瘦素、脂联素水平,改善氧化应激状态关系密切。
Objective：To investigate the effect of Zhenwu Decoction in the treatment of renal failure（type of Yang deficiency of spleen and kidney）patients on serum leptin and adiponectin.Methods：72 cases of renal failure（type of Yang deficiency of spleen and kidney）in our hospital from 2014.8 to 2016.9 were selected and divided into control group（n=36）and observation group（n=36）according to the random number table method,the control group was treated with reducing blood pressure,reducing blood sugar and controlling infection,and the observation group was treated more with Zhenwu Decoction treatment,and 2 groups were continuous treated for 3 weeks,levels of serum leptin,adiponectin,renal function,MDA,SOD,GSH-Px,and the clinical efficacy and adverse reaction conditions were compared.Results：The effective rate of the control group 72.22%（26/36）was lower than the observation group（33/36）,（P0.05）.Compared with before treatment,levels of serum leptin,adiponectin decreased in 2 groups after treatment,levels of serum Scr,BUN and UA decreased,Ccr increased,the serum MDA level decreased,the levels of serum SOD,GSH-Px increased（P0.05）,compared with the control group,levels of serum leptin,adiponectin in the observation group were lower,levels of serum Scr,BUN,UA level were lower,Ccr were higher,levels of serum MDA was lower,levels of serum SOD,GSH-Px were higher（P0.05）.Conclusion：Zhenwu Decoction for renal failure（spleen deficiency type）in patients was curative effect,it significantly improve renal function and decrease serum leptin and adiponectin,improve the relationship between oxidative stress.
出处
《辽宁中医药大学学报》
CAS
2018年第2期101-104,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
辽宁省中医药临床学(专)科能力建设项目(2013-Lnzyxzk-04)
辽宁省教育厅科学研究一般项目(L2012346)
辽宁省科学事业公益研究基金项目(2012002012)
沈阳市科技计划项目(F15-139-9-41)
关键词
真武汤
肾衰竭
脾肾阳虚型
瘦素
脂联素
肾功能
氧化应激
Zhenwu Decoction
renal failure
spleen deficiency type
leptin
adiponectin
renal function
oxidative stress
