摘要
目的:观察不同剂量百令胶囊联合常规治疗对慢性肾功能不全患者肾功能的影响。方法:80例慢性肾功能不全患者随机分为对照组和试验组各40例。两组患者均给予基础治疗及膳食平衡。在常规治疗基础上,对照组患者予百令胶囊1 g,po,tid;试验组患者予百令胶囊2 g,po,tid。两组疗程均为1个月。观察两组患者治疗前后血肌酐(SCr)、血尿素氮(BUN)、血清尿酸(UA)、血清胱抑素C(Cysc)、血清白蛋白(Alb)、血红蛋白(Hb)、24h尿蛋白定量、肾小球过滤率(e GFR)等指标变化情况。结果:治疗后,试验组SCr、BUN、血清UA和24 h尿蛋白均较前显著下降(P<0.001或P<0.01),e GFR则较前明显升高(P<0.05),而对照组各项指标治疗前后均无明显差异(P>0.05);试验组SCr和24h尿蛋白定量明显低于对照组治疗后(P<0.05)。结论:在常规治疗同时联合高剂量百令胶囊,可明显延缓慢性肾功能不全的进展。
Objective： To observe the effect of different doses of Bailing Capsule combined with conventional therapy on renal function in patients with chronic renal insufficiency. Methods： 80 patients with chronic renal failure were randomly divided into the control group and the experimental group,each 40 cases. The two groups were given basic treatment and dietary balance. On the basis of routine treatment,patients in the control group were treated with 1 g Bailing capsule three times a day,while the experimental group received 2 g Bailing capsule three times a day,and the two groups were observed for 1 month. The changes of serum creatinine（ SCr）,blood urea nitrogen（ BUN）,uric acid（ UA）,Cystatin-C（ Cysc）,serum albumin（ Alb）,hemoglobin（ Hb）,24 h urine protein quantitation,glomerulus filtration rate（ e GFR） between the two groups were observed and compared. Results： After treatment,SCr,BUN,UA and 24 h urinary protein in experimental group decreased significantly（ P〈0. 001 of P〈0. 01）,the e GFR increased obviously（ P〈0. 05）,while the indexes of the control group showed no significant difference before and after treatment（ P〉0. 05）; Compared with the control group,the SCr and 24 h urinary protein of the experimental group significantly lower（ P〈0. 05）. Conclusion： The high dose Bailing capsule combined conventional therapy obviously delayed the progression of chronic renal insufficiency.
出处
《药物流行病学杂志》
CAS
2018年第2期81-84,共4页
Chinese Journal of Pharmacoepidemiology
关键词
慢性肾功能不全
百令胶囊
剂量
Chronic renal insufficiency
Bailing capsule
Doses
