摘要
目的探讨年轻女性(≤35岁)乳腺癌(Breast carcinoma,BC)患者的临床病理特征、生存情况及影响预后的因素。方法回顾性分析2011年01月—12月间蚌埠医学院第一附属医院年轻乳腺癌患者61例。整理分析该组患者ER、PR、HER-2、p53表达情况,并探讨其与临床病理特征的关系,同时进行影响预后的相关因素分析;随访5年,分析影响该组患者5年无病生存率及5年总体生存率的因素。结果ER、PR、HER-2、P53的阳性率分别为78.7%(48/61),80.3%(49/61),32.8%(20/61),45.9%(28/61)。HER-2、p53表达在淋巴结转移组中比较,差异有统计学意义(P<0.05)。ER、PR表达在组织学分级、肿瘤大小及淋巴结转移各组中的差异无统计学意义(P>0.05)。Logistic回归分析结果显示,肿瘤直径、有无腋窝淋巴结转移、p53是影响年轻乳腺癌患者5年无病生存率的独立预后因素,有无腋窝淋巴结转移也是影响年轻乳腺癌5年总生存率的独立预后因素。5年OS和DFS为83.6%和70.5%。结论年轻乳腺癌患者的生物学行为恶性程度较高,预后较差,因此,对于有高危因素的年轻女性患者应采用积极的的预防筛查措施,争取早发现、早诊断、早治疗,降低病死率,提高患者生存质量。
Objective To analyze the clinical and pathological characteristics and prognosis of young women（ ≤35 years） suffering Breast carcinoma（ BC）. Methods Retrospective analysis on clinical data of 61 patients treated in Department of The First Affiliated Hospital of Bengbu Medical College during January 2011 and December 2011 was carried out in this study. The expression of ER,PR,HER-2 and p53 was analyzed,and the relationship between p53 expression and clinicopathological features was analyzed. The 5-year-free survival rate and 5-year overall survival rate were analyzed.Results The positive rates of ER,PR,HER-2 and P53 were 78.7%（ 48/61）,80.3%（ 49/61）,32.8%（ 20/61） and 45.9%（ 28/61）,respectively. The expression of HER-2 and p53 in lymph node metastasis group was statistically significant（ P〈0.05）. The expression of ER and PR in histological grading,tumor size and lymph node metastasis were not statistically different（ P〉 0. 05）. Logistic regression analysis showed that tumor diameter, P53 expression and axillary lymph node metastasis were independent prognostic factors influencing 5-year disease-free survival rate in young women. The axillary lymph node metastasis were independent prognostic factors influencing 5-year overall survival rate in young women. The5-year progression-free survival rate was 70.5% and the 5-year overall survival rate was 83.6 %.Conclusions Young breast cancer patients with high degree of malignancy and poor prognosis. Therefore,for young female patients with risk factors should adopt active preventive measures for screening, early diagnosis and early treatment,reduce mortality and improve the quality of life of patients.
出处
《齐齐哈尔医学院学报》
2017年第21期2506-2509,共4页
Journal of Qiqihar Medical University
关键词
乳腺肿瘤
预后
临床病理
年轻患者
Breast neoplasm
Prognosis
Clinical and pathological features
Young patient
