摘要
肿瘤细胞避免免疫系统破坏(免疫逃逸)是肿瘤发生发展的关键因素,肿瘤细胞表面的程序性死亡配体1(PD-L1)和细胞毒性T细胞表面的程序性死亡受体1(PD-1)相互作用导致免疫效应细胞失活,进而引起肿瘤细胞免疫逃逸和肿瘤进展。PD-L1有细胞膜型和可溶性分子两种形式,可溶性PD-L1能够与受体结合发挥生物学作用,既能影响肿瘤微环境中邻近细胞,也能通过血液循环作用于机体远处,其发挥作用的广度和深度有可能远超膜型分子。文章就可溶性PD-L1的来源、生物学功能及其在恶性肿瘤诊断和预后判断中的临床价值进行综述。
Tumor cells escape to immune surveillance（immune escape） is the key factor in the development and progression of tumors.Interaction between the Programmed Death Ligand 1（PD-L1） on the surface of tumor cells and the Programmed Death-1（PD-1） receptor on cytotoxic T lymphocytes suppresses the activation of T cells and evendually leads to immune escape and progression of tumors.PD-L1 has two isoforms,membrane-bound form and soluble form.Soluble PD-L1 has been proved to exert biological functions by combining with PD-1 as membrane PD-L1.Soluble molecules can affect adjacent cells,also play effective roles in the distance by circulation as cytokines.Thus soluble molecules might play more extensive effects than membrane molecules.In this review,we introduced the origin and biological functions of soluble PD-L1 and its clinical significance on diagnosis and prognosis of malignant tumors.
出处
《医学研究生学报》
CAS
北大核心
2018年第3期323-327,共5页
Journal of Medical Postgraduates
基金
国家自然科学基金(81270079
81570025)
