摘要
目的对比两种放化疗方式对晚期肺癌患者的疗效,探究放化疗晚期肺癌患者发生医院感染的危险因素。方法选取本院治疗的晚期肺癌患者100例,随机分为实验组和对照组,每组各50例。实验组患者采用同步放化疗,对照组患者采用序贯放化疗。比较两组患者的近期疗效。检测两组患者的医院感染情况。分别采用单因素分析和多元Logistic回归分析方法,分析年龄、性别等9个因素与患者医院感染的关系,确定危险因素。结果实验组有效率为64.00%,显著高于对照组的44.00%(P<0.05)。实验组不同病理类型、不同TNM分期的有效率均显著高于对照组(P<0.05)。患者的医院感染率为24.00%(24/100),最主要感染部位为呼吸道[50.00%(12/24)]。单因素分析结果显示,患者发生医院感染与住院时间、侵入性操作、陪护感染、白细胞、血清白蛋白及抗菌药物使用有显著相关性(P<0.05)。Logistic分析结果表明使用抗菌药物(OR=2.769)、住院时间>2个月(OR=2.704)、侵入性操作(OR=2.630)是患者发生医院感染的危险因素。结论相较于序贯放化疗,同步放化疗对晚期肺癌的近期疗效更佳;缩短住院时间、减少侵入性操作、合理应用抗菌药物可降低晚期肺癌患者发生医院感染的几率。
Objective To compare efficacy of two radiotherapy and chemotherapy methods in patients with advanced lung cancer, and to explore the risk factors of nosocomial infections. Methods 100 advanced lung cancer patients who underwent radiotherapy and chemo-therapy were collected as research subjects in our hospital from January 2014 to April 2017. All patients were randomly divided into experi-ment group and control group, 50 cases in each group. The patients in experiment group underwent concurrent chemoradiotherapy, and the patients in control group underwent sequential chemoradiotherapy. The short-term effects of patients between the two groups were com-pared. The nosocomial infections of patients in the two groups were detected. Single factor analysis and logistic analysis were used to analyze 9 factors including age and sex relations with nosocomial infection of advanced lung cancer patients in order to identify risk factors. Results The efficacy rate of patients in experiment group was 64.00%, which was significant higher than that in control group 44.00% （P〈0.05）. The efficacy rate of different pathological types and TNM periodizations in experiment group were significantly higher than those in control group （P〈0.05）. The nosocomial infection rate of advanced lung cancer patients underwent radiotherapy and chemotherapy was 24.00% （24/100）, in which the main position was respiratory tract [50.00% （12/24）] . The single factor analysis showed that length of stay, invasive procedure, attended infection, leukocyte, serum creatinine, serum albumin, and antimicrobial use were related factors of nosocomial infection （P〈0.05）.Logistic regression analysis showed anti-microbial use （OR=2.769）, length of stay 〉2 months （OR=2.704）, and invasive procedure （OR=2.630） were the risk factors of nosocomial infection patients. Conclusion Compare to sequential chemoradiotherapy, concurrent chemoradiotherap has better short-term effect. Shortening length of stay, reduced invasive procedures, and reasonable application of antimicrobial agents can reduce infection rate of nosocomial infections.
出处
《肿瘤药学》
CAS
2018年第1期84-88,共5页
Anti-Tumor Pharmacy
基金
四川省卫生厅科研项目(110119)
湖南省卫计委项目(C2015-52)
湖南省科技厅项目(2016JJ3083)
湖南省重点研发项目(2017SK2133)
关键词
晚期肺癌
同步放化疗
序贯放化疗
医院感染
危险因素
Advanced lung cancer
Concurrent chemoradiotherapy
Sequential chemoradiotherapy
Nosocomial infections
Risk factors
