摘要
目的 探讨塞来昔布用于食管癌患者放化疗过程中增敏效果及临床应用价值.方法 采用随机数字表法将60例食管癌患者分为观察组和对照组,每组30例,对照组给予常规放化疗,观察组联合塞来昔布进行放射增敏,对比两组临床疗效.结果 观察组总有效率46.67％ （14/30）,高于对照组的20.00％（6/30）,组间差异有统计学意义（x2=4.343,P＜0.05）.观察组发生放射性肺炎1例,放射性食管炎2例,放射性心肌炎1例;对照组发生放射性肺炎2例,放射性食管炎1例,放射性心肌炎2例,组间差异均无统计学意义（x2 =0.350、0.350、0.350,均P＞0.05）.观察组发生恶心呕吐7例,腹泻1例,骨髓抑制5例,肾毒性2例;对照组发生恶心呕吐8例,腹泻2例,骨髓抑制3例,肾毒性1例,组间差异均无统计学意义（x2 =0.088、0.350、0.576、0.350,均P＞0.05）.结论 塞来昔布应用于食管癌患者放化疗过程中可以起到增敏作用,可提高食管癌治疗效果,不增加不良反应,值得在临床上推广应用.
Objective To discuss the sensitization effect of celecoxib in the radiotherapy and chemotherapy of patients with esophageal cancer,and its clinical application value.Methods According to the digital table,60 patients with esophageal cancer were randomly divided into observation group and control group,30 cases in ecah group.The control group was given conventional radiation and chemotherapy,the observation group received combination with celecoxib for radiotherapy sensitization.The clinical effect was compared between the two groups.Results The total effective rate of the observation group was 46.67％ （14/30）,which was higher than 20.00％ （6/30） of the control group,the difference between the two groups was statistically significant （x2 =4.343,P ＜ 0.05）.In the observation group,radioactive pneumonia occurred in 1 case,radioactive esophagitis in 2 cases,radioactive myocarditis in 1 case.In the control group,radioactive pneumonia occurred in 2 cases,radioactive esophagitis in 1 case,radioactive myocarditis in 2 cases,the differences between the two groups were statistically significant （x2 =0.350,0.350,0.350,all P ＞0.05）.In the observation group,7 cases occurred nausea and vomiting,diarrhea in 1 case,bone marrow suppression in 5 cases,renal toxicity in 2 cases.In the control group,8 cases had nausea and vomiting,diarrhea happened in 2 cases,bone marrow suppression in 3 cases,renal toxicity in 1 case,there were no statistically significant differences between the two groups （x2 =0.088,0.350,0.576,0.350,all P ＞ 0.05）.Conclusion Application of celecoxib in patients with esophageal cancer during the process of radiation and chemotherapy has sensitization effect,it can promote the esophageal cancer treatment effect,without increase in adverse reactions,it is worthy of popularization and application in clinic.
出处
《中国基层医药》
CAS
2018年第1期14-17,共4页
Chinese Journal of Primary Medicine and Pharmacy
基金
浙江省金华市科学技术研究计划项目（2015-3-087）
