摘要
目的:探讨禁欲天数对宫腔内人工授精(intra-uterine insemination,IUI)妊娠率的影响。方法:回顾性分析男方精液参数正常,因女方排卵障碍或宫颈因素或不明原因不孕行IUI助孕治疗不孕夫妇的数据,按禁欲天数的不同分为三组:A组(禁欲天数≤2d)、B组(禁欲天数3~5d)、C组(禁欲天数>5d),比较三组之间的妊娠率。结果:共纳入106例(190周期)患者,其中A组27周期,B组110周期,C组53周期,三组处理前以及处理后的前向运动精子总数随着禁欲天数的增加逐渐增加,且差异有统计学意义[三组处理前分别为:55.6±37.6、65.0±41.5和102.1±65.5(×10~6),处理后分别为20.7±12.6、22.7±12.2和30.7±14.5(×10~6),P均<0.05]。三组的周期妊娠率分别为22.2%(6/27)、10.9%(12/110)和15.1%(8/53),三组比较差异无统计学意义(P>0.05)。进一步比较临床妊娠组(n=26)与无妊娠组(n=164)两组间的禁欲天数,结果提示差异也无统计学差异[4.0(2.8,7.0)比4.0(3.0,6.0),P>0.05]。二分类Logistic回归分析亦显示禁欲天数并不与IUI妊娠率相关。结论:对于男方精液参数正常的不孕夫妇来说,随着禁欲天数的增加,处理前后的前向运动精子总数增加。禁欲天数≤2d可能获得较高的妊娠率,然而不同的禁欲天数之间比较,其周期妊娠率无显著差异,需要更进一步的研究。
Objectives： To investigate the effect of ejaculatory abstinence period on the pregnancy rate after intrauterine insemination（ IUI）. Methods： The data of infertile couples with a normal comprehensive semen analysis who underwent IUI treatment as result of ovulatory disorder or cervical factor infertility or unexplained infertility were retrospectively reviewed. According to the ejaculatory abstinence period,three groups were identified： group A（ up to 2 days）,group B（ 3 to 5 days） and group C（ 5 days）. The pregnancy rates were compared among these groups. Results： 106 patients（ 190 cycles） were included. 27 cycles were in group A,110 cycles were in group B,and 53 cycles were in group C. The total progressively mobile sperm counts pre-and post-wash correlated positively with the ejaculatory abstinence period [total progressively mobile sperm count pre-wash： 55. 6 ± 37. 6,65. 0 ± 41. 5 and 102. 1 ± 65. 5（ × 106）,respectively; total progressively mobile sperm count post-wash： 20. 7 ±12. 6,22. 7 ± 12. 2 and 30. 7 ± 14. 5（ × 106）,respectively; P〈0. 05]. The cycle pregnancy rate of group A,B,and C were 22. 2%（ 6/27）,10. 9%（ 12/110） and 15. 1%（ 8/53）. No significant differences were found（ P〈0. 05）. The ejaculatory abstinence period was further compared between clinical pregnancy group and no pregnancy group,and no significant difference was found（ P〈0. 05）. Also,the binary logistic regression model showed no relationship between the ejaculatory abstinence period and IUI pregnancy rate. Conclusion： For those couples with a normal comprehensive semen analysis,the total progressively mobile sperm counts pre-or post-wash are correlated positively with the ejaculatory abstinence period. It seems that an abstinence interval of 2 days or less might be associated with higher pregnancy rates. However,no significant differences are found and further studies are required.
出处
《中国性科学》
2018年第1期82-85,共4页
Chinese Journal of Human Sexuality
基金
广东省中山市科技计划项目(2015B1023)
关键词
禁欲天数
前向运动精子总数
宫腔内人工授精
妊娠率
Ejaculatory abstinence
Total progressively mobile sperm count
Intrauterine insemination（IUI）
Pregnancy rate
