摘要
醋酸泼尼松、消炎痛、葛根黄豆甙元与预胶化淀粉制备的研磨混合物,在体外实验中主药溶出较原药粉末及物理混合物明显加快。运用粉末直接压片工艺将研磨混合物制备的片剂,其主药的溶出也较市售片有很大程度的提高。研究表明,当药物与预胶化淀粉的比例为1:5时,经过90 min 研磨制得的混合物中,药物以无定形态存在,且以极微小的粒子分布在淀粉表面。
Ground mixtures(GM)of prednisone acetate(PA),indomethacin(IM),daidzein(DD)with pregelatinized starch(PGS)were prepared.The dis-solution test in vitro indicated that GM powder gave a higher rate of dissolutionthan physical mixture(PM)or intact drug powder and that the dissolution rateof drugs from the tablets prepared with GM powder was also significantly greaterthan that from commercial tablets.The various studies suggested that when theweight ratio of each drug with pregelatinized starch was 1:5,drug in GM powderwas in an amorphous state after 90 min of grinding.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1991年第11期493-497,共5页
Chinese Journal of Pharmaceuticals
关键词
制剂
难溶性药物
溶出机理
prednisone acetate
indomethacin
daidzein
pregelatinized starch
ground mixture
dissolution
mechanism
