摘要
目的研究醒脑静注射液对老年重症脑梗死患者的临床疗效及对血清血管内皮生长因子(vascular endothelial growth factor,VEGF)、白细胞介素-8(interleukin-8,IL-8)表达水平的影响。方法选择2016年5月至2017年6月在河北省人民医院神经内科住院的老年重症脑梗死患者共86例,按照随机数字表法分为醒脑静注射液治疗组和对照组,每组43例。对照组采用常规内科治疗,治疗组在对照组治疗基础上加用醒脑静注射液20 ml加入0.9%氯化钠溶液250 ml静脉点滴,1次/d,2组患者均连续治疗14 d。比较2组患者治疗前后脑卒中患者临床神经功能缺损程度评分(clinical neurological deficit scale,CNDS)及临床总有效率,并采集血清样本,化验治疗前后VEGF、IL-8水平。结果治疗后,治疗组及对照组CNDS均较治疗前显著降低,同时治疗组改善程度优于对照组,差异有统计学意义(P<0.05)。治疗组总有效率为67.4%,对照组总有效率为44.2%,2组差异有统计学意义(P<0.05)。治疗14 d后,2组血清VEGF水平均较前升高,治疗组水平明显高于对照组,2组比较差异有统计学意义(P<0.05);2组IL-8水平均较前降低,治疗组水平低于对照组,二者比较差异有统计学意义(P<0.05)。结论醒脑静注射液治疗老年重症脑梗死患者具有较好疗效,可显著改善脑梗死患者血清VEGF、IL-8的介质水平,从而促进患者神经元功能及意识障碍的恢复,值得临床推广应用。
Objective To observe the therapeutic effects of Xingnaojing injection on senile severe cerebral infarctionand and its effects on serum levels of vascular endothelial growth factor（ VEGF） and interleukin-8（ IL-8）. Methods Eighty-six patients with senile severe cerebral infarction who were admitted and treated in our hospital from May 2016 to June 2017 were randomly divided into Xingnaojing treatment group（ n = 43） and control group（ n = 43）. The patients in control group were treated by conventional therapy,however,the patients in Xingnaojing treatment group,on the basis of control group,were treated by Xingnaojing injection（ 20ml/250 ml saline,once a day）,with a treatment course of 14 d for both groups. The clinical neurological deficit scale（ CNDS）,the changes of serum levels of VEGF and IL-8 before and after treatment were observed and cpompared between two groups. Results The CNDSs were significantly decreased after treatment in both groups,moreover,which in Xingnaojing treatment group were superior to those in control group（ P 〈0. 05）. The total effective rate in Xingnaojing treatment group and control group was 67. 4% and 44. 2%,respectively,there was significant difference between two groups（ P 〈0. 05）. After 14-day treatment,the serum levels of VEGF were increased in both groups,moreover,which in Xingnaojing treatment group were significantly higher than those in control group（ P 〈0. 05）,however,the serum levels of IL-8 were decreased in both groups,moreover,which in Xingnaojing treatment group were significantly lower than those in control group（ P 〈0. 05）. Conclusion Xingnaojing injection has better therapeutic effects on senile severe cerebral infarction,which can significantly improve the serum levels of VEGF and IL-8 so as to promote the recovery of neuron function and consciousness disorders,therefor,which is worth using widely in clinical practice.
出处
《河北医药》
CAS
2018年第3期393-396,共4页
Hebei Medical Journal
关键词
老年重症脑梗死
醒脑静注射液
血管内皮生长因子
白细胞介素-8
senile severe cerebral infarction
Xingnaojing injection
vascular endothelial growth factor
interleukin-8
