摘要
目的探讨炎性因子、N端脑钠肽前体(NT-ProBNP)在心力衰竭伴肺部感染患者的水平变化及临床意义。方法选取2013年1月至2017年1月收治的142例慢性心力衰竭作为研究对象,根据是否合并肺部感染分为单纯心力衰竭组(n=79)和合并感染组(n=63),比较患者血清白介素(IL)-6、肿瘤坏死因子-α(TNF-α)和NT-ProBNP水平。结果选合并感染组血清TNF-α、IL-6、NT-ProBNP水平及LVEDD均明显高于单纯心力衰竭组,LVEF低于单纯心力衰竭组(P<0.05);合并感染组心功能Ⅳ级患者血清TNF-α、IL-6、NT-ProBNP水平明显高于Ⅱ级和Ⅲ级患者(P<0.05);合并感染组患者住院期间不良事件发生率明显低于单纯心力衰竭组(P<0.05);合并感染组有主要不良事件患者血清TNF-α、IL-6及NT-ProBNP水平均明显高于无主要不良事件患者(P<0.05);TNF-α、IL-6、NT-ProBNP与LVEF呈明显负相关性(r<0,P<0.05),与LVEDD、心功能分级呈明显正相关性(r>0,P<0.05)。结论选在心力衰竭伴肺部感染患者中血清TNF-α、IL-6及NT-ProBNP水平明显升高,且与患者心功能密切相关,可作为患者病情严重程度及短期预后评估的重要指标。
Objective To investigate the changes and clinical significance of levels of inflammatory factors and N terminal brain natriuretic peptide（ NT-ProBNP） in patients with heart failure complicated by pulmonary infection. Methods A total of 142 patients with heart failure complicated by pulmonary infection who were admitted and treated in our hospital from January 2013 to January 2017 were enrolled in the study. According to whether the patients with heart failure were complicated by pulmonary infection or not,these patients were divided into simple heart failure group（ n = 79） and concurrent infection group（ n = 63）,then the serum levels of interleukin（ IL）-6,tumor necrosis factor-α（ TNF-α） and NT-ProBNP were observed and compared between the two groups. Results The serum levels of serum TNF-α,IL-6,NT-ProBNP and LVEDD in concurrent infection group were significantly higher than those in simple heart failure group,however,the levels of LVEF were significantly lower than those in simple heart failure group（ P 〈0. 05）. The serum levels of TNF-α,IL-6 and NT-ProBNP in patients with cardiac function grade Ⅳ in concurrent infection group were significantly higher than those in patients with cardiac function grade Ⅱ and gade Ⅲ（ P 〈0. 05）. The incidence rates of adverse events in concurrent infection group were significantly lower than those in simple heart failure group（ P 〈0. 05）,moreover,the serum levels of TNF-α,IL-6 and NT-ProBNP in patients with major adverse events in concurrent infection group were significantly higher than those of patients without major adverse events（ P 〈0. 05）. Moreover the TNF-α,IL-6,NT-ProBNP were closely negatively correlated with LVEF（ r 0,P 0. 05）,however,which were closely positively correlated to LVEDD and cardiac function classification（ r 0,P 0. 05）. Conclusion The serum levels of TNF-α,IL-6 and NT-ProBNP are obviously increased in patients with heart failure complicated by pulmonary infection,moreover,which are closely related with the cardiac function of patients,therefor,which can be regarded as important indexes of evaluating the severity of disease and short-term prognosis of patients.
出处
《河北医药》
CAS
2018年第3期329-331,336,共4页
Hebei Medical Journal
关键词
慢性心力衰竭
肺部感染
炎性因子
N端脑钠肽前体
chronic heart failure
pulmonary infection
inflammatory factors
N terminal brain natriuretic peptide
