摘要
为寻找高效低毒、结构简单的鬼臼毒素类新药,以4-溴-4′-去甲基-4-脱氧表鬼臼毒素和过量醇合成了13个新的4′-去甲基表鬼臼毒素-4-醚衍生物。所有这些化合物对体外 L1210试验,均有抑制活性,其中5个化合物的抑制活性与 etoposide 相近。
To search for the new potent and less toxic antitumor podophyl-lotoxin derivatives,thirteen new 4′-demethylepipodophyllotoxin-4-ethers were syn-thesized from 4-bromo-4′-demethyl-4-deoxyepipodophyllotoxin and excess alcoholswithout any catalyst in moderate to high yields.In vitro test,these compoundsshowed antitumor activity against leukemia L1210.Five of them exhibited theactivity comparable to that of etoposide.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1991年第10期446-449,共4页
Chinese Journal of Pharmaceuticals
关键词
鬼臼毒素
抗肿瘤活性
合成
醚
podophyllotoxin
ethers
antitumor
synthesis
