摘要
目的:通过Meta分析评价维生素预防冠状动脉造影术后对比剂肾病(CIN)的作用。方法:检索Pub Med、MEDLINE、Cochrane Library Central Register of Controlled Trials、Clinical Trails.gov数据库中关于CIN预防的相关文献,检索时间均从建库至2016-12。按纳入标准、排除标准选择符合条件的随机对照研究(RCT),并提取数据。采用Rev Man 5.3统计软件行Meta分析。结果:共纳入11项RCT,患者1 810例,其中维生素类组有951例,安慰剂组有859例,各研究平均年龄在60~73岁,男性比例45.9%~92.2%。Meta分析结果显示,维生素类组CIN发生率明显低于安慰剂组(RR=0.54,95%CI:0.39~0.73);与安慰剂组相比,维生素类组维生素类药物的使用可使冠状动脉造影术后CIN发生率降低46%。使用维生素C患者的CIN发生率较安慰剂组明显降低(RR=0.58,95%CI:0.37~0.90);与安慰剂组相比,维生素C可以使冠状动脉造影术后CIN发生率下降42%。结论:维生素类药物可使冠状动脉造影术后的CIN发生率降低46%,其中维生素C可使CIN发生率下降42%。
Objective： To evaluate the effects for vitamins preventing contrast induced nephropathy（CIN） in patients after coronary angiography（CAG） by Meta-analysis.Methods： We searched PubM ed, Medline, Cochrane library central register of controlled trials and ClinicalT rails. gov from the database establishment to 2016-12 for CIN related references. According to enrollment and elimination standards, we chose eligible randomize control trail（RCT）, extracted data and conducted a Meta-analysis using RevM an 5.3 statistical software.Results： A total of 11 RCTs with 1810 patients were enrolled which included in 2 groups： Vitamins group, n=951 and Placebo group, n=859. The average age of patients was（60-73） years and the male was（45.9-92.2） %. Meta-analysis showed that CIN occurrence rate in Vitamins group was lower than Placebo group（RR=0.54, 95% CI 0.39-0.73）; compared with Placebo group, the incidence of CIN was decreased by 46% in Vitamins group. Using Vitamin C could decrease CIN occurrence rate（RR=0.58, 95% CI 0.37-0.90）; compared with Placebo group, the incidence of CIN was decreased by 42% for using Vitamin C.Conclusion： Vitamins can reduce 46% incidence of CIN and Vitamin C may reduce 42% incidence of CIN in patients after CAG.
作者
唐庚
马根山
TANG Geng;MA Gen-shan.(Department of Clinical Medicine, Southeast University Medical School, Nanjing （210000）, Jiangsu, China)
出处
《中国循环杂志》
CSCD
北大核心
2018年第2期181-186,共6页
Chinese Circulation Journal
