摘要
目的研究CAPN4(calpain small subunit 1)在结直肠癌中的表达及其临床意义。方法免疫组织化学法检测10对结直肠癌组织和相应的癌旁非瘤组织中CAPN4的表达,并检测74例结直肠癌组织中CAPN4的表达,结合临床随访资料探讨其表达与临床病理因素和预后的相关性。结果结直肠癌组织中CAPN4的表达均高于相应的癌旁非瘤组织。CAPN4的表达强度与结直肠癌患者的Dukes分期(P=0.000),TNM分期(P=0.000),病理分级(P=0.021)和生存预后(P=0.040)显著相关,而与患者的年龄和性别无相关性。Kaplan-Meier分析显示,CAPN4高表达病例组生存时间明显少于CAPN4低表达病例组,经Log-rank检验,差异有统计学意义。结论 CAPN4在结直肠癌中表达上调,其表达差异与结直肠癌Dukes分期、TNM分期、病理分级和患者生存预后呈显著负相关,提示其可能与结直肠癌的发生、发展相关。
Objective To investigate the expression and clinica｜ significance of calpain small subunit 1 （CAPN4） in colorectal cancer（CRC）. Methods The expression of CAPN4 was detected by immnnohistoehemistry in 10 cases of CRC tissues and the adjacent non - tumor tissues and 74 samples CRC tissues. Clinieopathological data was analyzed to reveal the correlation between CAPN4 expres- sion and clinicopathologieal characteristics and prognosis of CRC patients. Results Immunohistochemistry analysis showed that CAPN4 expression in CRC tissues was higher than that in adjacent non - tumor tissues. CAPN4 expression was significantly correlated with Dukes＇ stages （ P = 0. 000） , TNM stages （ P = 0. 000） , histopathological grading （ P = 0. 021 ） and prognosis （ P = 0.04） , whereas CAPN4 ex- pression was not correlated with patient age and gender. Kaplan - Meier analysis demonstrated that high CAPN4 expression was correlated with a short survival time. Coloeusion The increased expression of CAPN4 was significantly correlated with Dukes＇ stages, TNM stages, histopathologieal grading and prognosis in CRC, indicating that it may play a role in the oncogenesis and development of CRC.
出处
《医学研究杂志》
2018年第2期58-61,共4页
Journal of Medical Research
基金
国家自然科学基金资助项目(81402310)
深圳市科技计划项目(JCYJ20140411093600199)
