摘要
当苯妥英与醋酸锌摩尔比为2∶1时,苯妥英锌成盐收率为92.8%。小鼠腹腔注射的 ED_(50)和 LD_(5)分别为9.74和138.1 mg/kg。与苯妥英钠相比,吸湿性和对眼的刺激性较小,在大鼠口服的亚急性毒性试验中,Hb、BP、WBC、SGPT 阳病理组织学检查表明两药的毒性无显著差异。
Zinc Phenytoin(Ⅱ)was prepared from phenytoin and zinc
acetate in molar ratio 2:1 with 92.8% yield.ED_(50) and LD_(50) of Ⅱ(mice,ip)
were 9.74 and 138.1 mg/kg,respectively.Hygroscopicity and irritation to eyes
of Ⅱ were less than sodium phenytoin(Ⅰ).No significant differences were
observed between Ⅱ and Ⅰ in Hb,BP.WBC and SGPT as well as histopathological
examination in subacute toxicity test(rat,po).
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1991年第7期308-310,共3页
Chinese Journal of Pharmaceuticals
关键词
苯妥英锌
吸湿性
刺激性
毒性
zinc phenytoin
sodium phenytoin
hygroscopicity
irritation
subacute toxicity
