摘要
采用逆相蒸发法制得稳定的 SOD 脂质体,其包封率为54.76±4.81%。研究了两种 SOD 脂质体(Ⅰ和Ⅱ)在兔体内的药物动力学,其半衰期分别为5.94±1.95h 和5.85±2.11h。小鼠给予脂质体Ⅱ后SOD 活性以脾、肺和肝组织中最高,肾、心、脑次之,胃中无规律性。
SOD liposome was prepared with a steady encapsulation rate(54.76±4.81%)by reverse-phase evaporation method.The elimination half-life ofSOD after po of SOD liposome Ⅰ and Ⅱ was 5.94±1.95h and 5.85±2.11h,respec-tively.The distribution following po of liposome Ⅱ in mice was studied.The resultsshowed that SOD activity in spleen,lung and liver was the highest,then came nextin kidney,heart and brain,but irregular in stomach.The results demonstratedthat SOD level could be elevated by liposome encapsulation.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1991年第7期296-298,315,共4页
Chinese Journal of Pharmaceuticals
