摘要
缓释评价指数(SREI)包括四个参数:反映给药间期血药浓度在最小有效浓度(MEC)以上的时间分数的缓释时间指数(SRTI);反映起效快慢和有效时间长短的有效持续时间(ED);将 C_(max)与理想有效浓度相比较的最佳有效浓度指数(OECI)和反映血药浓度时间曲线在 MEC 以上的面积的校正有效治疗面积(CETA)。用以上四个参数较用传统的 AUC,T_(max)和 C_(max)能更好地比较缓释制剂的优劣。
The SREI are composed of 4 parameters:(1)The sustained re-lease time index(SRTI)is the ratio of the time when the drug concentration inblood is higher then MEC(minimal effective concentration)to the administra-tion interval.(2)The effective duration(ED)is t_1～t_2,where t_1 is the timewhen the drug concentration in blood reaches MEC after administration,t_2 is the time when the concentration drops to MEC and t_2-t_1 is the time period whenthe concentration is maintained above MEC.(3)The optimum effective concentra-tion index(OECI)is the ratio of the C_(max) to the Mean value of MEC and MTC(minimal toxic concentration).(4)The correct effective therapeutic area(CETA)is the area under blood drug concentration-time curve above MEC,correctedwith SRTI.It is suggested that the SREI be used to evaluate the sustainedrelease preparations more rationally than the traditional parameters(AUC,C_(max)and T_(max)).
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1991年第6期260-263,共4页
Chinese Journal of Pharmaceuticals
关键词
制剂
缓释
缓释评价指数
评价
preparation
sustainted release
SREI
evaluation
