摘要
整合素是多细胞生物中必需且丰富的异二聚体细胞表面黏附受体,其通过细胞质结构域与多种细胞内信号转导和衔接蛋白(如整合素连接激酶、黏着斑激酶等)的直接或间接相互作用来调节穿过质膜的双向信号转导。转化生长因子β(TGF-β)信号通路是一个包含众多成员的多功能细胞因子的大家族,形成一个多功能、密切联系的细胞因子网络。整合素与TGF-β两条信号通路不仅共用某些信号分子,还共同作用于多种生物学效应并相互促进。
Integrins are essential and abundant heterodimeric cell-surface adhesion receptors in multicellular organisms that interact with a variety of intracellular signal transduction and adapter proteins( such as integrin-linked kinases,focal adhesion kinase,etc.) to regulate bidirectional signal transduction across the plasma membrane. Transforming growth factor β( TGF-β) signaling pathway is a large family of multifunctional cytokines that form a multifunctional,closely related network of cytokines. Integrins and TGF-β signaling pathways not only share certain signal molecules,but also act on a variety of biological effects and promote each other.
出处
《医学综述》
2018年第2期220-225,共6页
Medical Recapitulate
基金
国家自然科学基金面上项目(81771562)
