摘要
目的:观察生长抑素与丹参川芎嗪注射液对高脂血症性重症急性胰腺炎(hyperlipidemic severe acute pancreatitis,HLSAP)患者预后的影响。方法:选取2011年1月至2017年3月我院收治的80例HL-SAP患者,随机分为观察组(生长抑素联合丹参川芎嗪注射液)和对照组(生长抑素),每组各40例,分别比较两组临床症状(腹痛消失时间、肛门首次排气时间)、生化指标(血淀粉酶及血钙恢复正常时间)、血液粘度指标[血甘油三酯(TG)、全血高切粘度值、全血低切粘度值]、血管内皮细胞合成因子[血浆一氧化氮(NO)、内皮素-1(ET-1)]水平。结果:观察组患者的腹痛消失时间、肛门首次排气时间、血淀粉酶及血钙恢复正常时间分别为(2.96±1.53)、(4.72±1.58)、(5.28±1.09)、(5.45±1.31),均较对照组短(P<0.05)。治疗15d后观察组血清TG、全血高切粘度值、全血低切粘度值、血NO、血ET-1水平分别(6.58±1.78)、(5.66±0.72)、(10.54±0.98)、(77.19±15.89)、(90.79±21.08),均优于对照组,差异有统计学意义(P<0.05)。结果:生长抑素联合丹参川芎嗪注射液可降低血粘度、保护患者内皮细胞功能,改善HL-SAP患者预后情况。
Objective: To observe the effect of somatostatin and Salvia miltiorrhiza ligustrazine injection on the prognosis of hyperlipidemic severe acute pancreatitis( HL-SAP) patients. Methods: 80 patients with HL-SAP were enrolled from January 2011 to March 2017,and were randomly divided into treatment group( somatostatin combined with Salvia miltiorrhiza ligustrazine injection)and control group( somatostatin),each group had 40 cases. Clinical symptoms( abdominal pain disappeared time and the first time of the anus exhaust),biochemical indicators( blood amylase,blood calcium returned to normal time),blood viscosity index( blood triglycerides,whole blood high shear viscosity value and whole blood low shear viscosity value),vascular endothelial cell synthesis factor [Plasma NO and endothelin-1( ET-1) levels] were compared. Results: Abdominal pain disappeared time,the first time of the anus exhaust, blood amylase and blood calcium returned to normal time of the treatment group were respectively( 2. 96 ± 1. 53),( 4. 72 ± 1. 58),( 5. 28 ± 1. 09) and( 5. 45 ± 1. 31),which were shorter than those of the control group( P < 0. 05). The levels of serum TG,total blood high shear viscosity,whole blood low shear viscosity,blood NO and blood ET-1 were respectively( 6. 58 ± 1. 78),( 5. 66 ± 0. 72),( 10. 54 ± 0. 98),( 77. 19 ± 15. 89),( 90. 79 ± 21. 08) which were better than those of the control gorup. The differences were statistically significant( P < 0. 05). Conclusion: Somatostatin combined with Salvia miltiorrhiza ligustrazine injection can reduce blood viscosity and protect the endothelial cell function,improve the prognosis of patients with HL-SAP.
出处
《中国医药导刊》
2017年第12期1333-1336,共4页
Chinese Journal of Medicinal Guide
关键词
高脂血症性重症急性胰腺炎
生长抑素
丹参川芎嗪注射液
Hyperlipidemic severe acute pancreatitis
Somatostatin
Salvia miltiorrhiza ligustrazine injection
