摘要
目的探讨磁共振谷氨酸化学交换饱和转移成像技术诊断脑肿瘤的价值及其可行性。方法对2014年4月~2015年4月于汕头大学医学院附属第二医院经手术或临床确诊的28例脑肿瘤患者进行MRI检查,年龄23~80岁。患者于静息状态下应用GE 3.0 T Signa磁共振扫描仪进行常规的T1WI、T2WI扫描,以及应用自行设计的化学交换饱和转移序列,在偏离水质子峰3.0 ppm处激发特定的脉冲进行扫描,并经计算机处理后与常规序列进行对比分析。同时患者也在该机器上进行氢质子磁共振波谱成像用于数据融合对比。结果对得到的谷氨酸化学交换饱和转移(Glu CEST)成像进行对比分析,胶质瘤瘤体及瘤体周边组织呈明显高信号改变;转移瘤瘤体呈低信号改变,瘤体周边组织呈明显高信号改变;而脑膜瘤瘤体呈低信号改变;以上Glu CEST成像中区域信号改变大致符合氢质子磁共振波谱中谷氨酸浓度定量改变。结论谷氨酸化学交换饱和转移成像作为一种新起的磁共振成像技术,能为脑肿瘤及瘤周情况提供更丰富的代谢物信息,对脑肿瘤的诊断、治疗及预后提供更好的帮助。
Objective The purpose of this study was to evaluate the diagnosis value and the feasibility of the glutamate chemical exchange saturation transfer（GluCEST） method for the diagnosis of brain tumor patients using 3.0 T MR scanner. Methods A total of 28 patients with brain tumor treated in the Second Affiliated Hospital of Shantou University Medical College were recruited for this study. Conventional T1, T2 weitghed images as well as the GluCEST images were acquired using a 3.0 T clinical scanner（Signa, GE） . GluCEST imaging was acquired at 3.0ppm away from water peak, in order to calculate the magnetization transfer ratio asymmetry. Proton magnetic resonance spectroscopy was also acquired at 3.0 T and used for data co-registration and comparison. Results Tumor and the surrounding tissues showed obviously hyper-intensity in the GluCEST imaging of the glioblastoma. Metastatic neoplasm showed hypo-intensity in tumor and hyper-intensity in the surrounding tissues. Meningioma showed hypo-intensity in tumor. The GluCEST regional distribution approximated to glutamate variations quantified detected by 1H-MRS. Conclusion As a novel magnetic resonance imaging technique, GluCEST can provide more information about the metabolites of brain tumor, which could contribute to theclinical diagnosis and prognosis.
出处
《功能与分子医学影像学（电子版）》
2017年第4期1295-1301,共7页
Functional and Molecular Medical Imaging(Electronic Edition)
基金
国家自然科学基金(81471730)
关键词
化学交换饱和转移
脑肿瘤
3.0T
chemical exchange saturation transfer
brain tumor
3.0 tesla
