摘要
目的:研究疏肝软坚颗粒联合复方甘草酸苷对慢性重度乙型肝炎患者的抗纤维化作用。方法:选取慢性重度乙型肝炎并肝纤维化的患者60例,随机分为两组,治疗组(30例)给予疏肝软坚颗粒联合复方甘草酸苷100 mg,3次/d,口服,对照组(30例)给予葡醛内酯片200 mg,3次/d,口服,治疗时间为6个月,比较两组患者临床疗效、肝纤维化指标以及肝穿情况。结果:患者肝纤四项较对照组明显降低,差异有显著性(P<0.05),肝组织活检结果提示两组患者肝纤维化程度均较治疗前有所好转,但治疗组优于对照组,差异有显著性(P<0.05);两组抗肝纤维化的总体有效率,治疗组明显优于对照组,差异有显著性(P<0.05)。结论:疏肝软坚颗粒联合复方甘草酸苷有较好的抗肝纤维化作用。
Objective: To study the anti-fibrosis effect of the Shugan Ruanjian granule plus compound glycyrrhizin on chronic severe hepatitis B. Method: 60 patients with chronic severe hepatitis B and hepatic fibrosis were randomly divided into two groups. The treatment group(30 cases) were treated with the Shugan Ruanjian granule plus compound glycyrrhizin, 100 mg, 3 times/d orally. The control group(30 cases) were given benzaldehyde lactone tablets, 200 mg, 3 times/d orally, for 6 months, the clinical efficacy, liver fibrosis index and liver condition in two groups were compared. Results: The liver fibrosis in the treatment group was significantly decreased than that in the control group(P<0.05), and the improvement of the liver fibrosis in the treatment group was significantly higher than that in the control group(P<0.05). The overall effective rate of anti-hepatic fibrosis in the treatment group was significantly higher than that in the control group(P<0.05). Conclusion: The Shugan Ruanjian granule plus compound glycyrrhizin had a good anti-liver fibrosis effect.
出处
《中医临床研究》
2017年第36期38-40,共3页
Clinical Journal Of Chinese Medicine
