摘要
目的探讨添加ω-3鱼油脂肪乳的全胃肠外营养(TPN)支持对行腹腔镜结直肠癌术(LCS)患者免疫功能的影响。方法选取2016年2月至2017年2月该院普外科收治的行LCS患者150例,采用随机数字表法分为A、B、C组,每组50例。A组采用TPN[给予脂肪乳氨基酸(17)葡萄糖(11%)注射液],B组采用TPN联合ω-3鱼油脂肪乳,C组予以常规补液。分别于术前1 d,术后第1、5天检测三组患者免疫学指标[体液免疫指标(免疫球蛋白A、G、M水平)和细胞免疫指标(CD3+、CD4+、CD8+水平)],并进行统计学分析。比较三组患者住院时间和并发症发生情况。结果三组患者术前各项免疫学指标比较,差异均无统计学意义(P>0.05);三组患者术后第1天各项免疫学指标均明显优于术前1 d,差异均有统计学意义(P<0.05),但组间比较,差异均无统计学意义(P>0.05);三组患者术后第5天免疫学指标均有不同程度恢复,其中B组恢复最明显,与其他两组比较,差异均有统计学意义(P<0.05)。B组患者住院时间明显短于A、C组,A组患者住院时间明显短于C组,差异均有统计学意义(P<0.05)。B组患者术后并发症发生率明显低于C组,差异有统计学意义(P<0.05);A组患者术后并发症发生率与B、C组比较,差异均无统计学意义(P>0.05)。结论添加ω-3鱼油脂肪乳的TPN可有效促进LCS患者的免疫功能,缩短住院时间。
Objective To investigate the effect of total parenteral nutrition(TPN)support adding ω-3 fish oil emulsion on the immune function after laporoscopic colorectal cancer surgery(LCS).Methods One hundred and fifty patients with LCS in the department of general surgery in this hospital from February 2016 to February 2017 were selected and divided into the group A,B and C by adopting the random number tablemethod,50 cases in each group.The group A adopted TPN for giving fat milk amino acid(17)glucose(11%)injection,the group B adopted TPN combined with ω-3 fish oil fat emulsion and the group C adopted the routine fluid infusion.The immunological indexes[humoral immunity indicators such as immunoglobulin A,G and M levels and cellular immunity indicators such as CD3+,CD4+ and CD8+ levels were detected on preoperative 1 d,postoperative 1,5 d.Then the statistical analysis was performed.The hospitalization time and occurrence situation of complications were compared among 3 groups.Results The various immunological indexes before operation had no statistical difference among 3 groups(P>0.05);the various immunological indexes on postoperative 1 d in 3 groups were significantly better than those before operation,the difference was statistically significant(P<0.05),but the inter-group comparison showed no statistical difference(P>0.05);the immunological indexes on postoperative 5 d in 3 groups had different degrees of recovery,in which the recovery in the group B was most obvious,the difference had statistical significance compared with other two groups(P<0.05).The hospitalization time in the group B was significantly shorter than that in the group A and C and the hospitalization time in the group A was significantly shorter than that in the group C,the difference was statistically significant(P<0.05).The occurrence rate of postoperative complications in the group B was significantly lower than that in the group C,the difference had statistical significance(P<0.05);the occurrence rate of postoperative complications had no statistical difference between the group A with the group B and C(P>0.05).Conclusion TPN adding ω-3 fish oil fat emulsion can effectively promote the immune function in the patients with LCS and shortens the hospitalization time.
出处
《现代医药卫生》
2018年第1期41-43,55,共4页
Journal of Modern Medicine & Health
