摘要
溶出度是口服固体制剂的质量指标之一,用以保证药物吸收及生物利用度。改善溶出度主要依靠提高崩解度或释放度,药物微粉化或分布于载体以增加表面积及采用其它增溶措施。可选择适当的崩解剂、助溶或增溶性添加剂,改进混合、制粒等工艺和采用载体分散体系,通过器械粉碎或微粉化、微晶化处理以及采用喷雾干燥、冷冻干燥等。
The means for the improvement of dissolution mainly involevthe improvement of disintegration or release of the drug;micronization or mi-crocrystallization of the drug or distribution of the drug on carriers in orderto increase surface area and the solubilization or lyophilization measures.In practice,selection of appropriate disintegrants and the order of mixing andblending are decisive in many cases.Spray-drying and freeze-drying will also beadvantageous.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1991年第3期131-135,共5页
Chinese Journal of Pharmaceuticals
关键词
溶出度
生物利用度
固体制剂
口服
dissolution
bioavailability
micronization
ordered mixing
