摘要
目的:观察补阳还五汤对2型糖尿病合并脑梗死患者血清超敏C反应蛋白(high-sensitivity C-reactive protein,hsCRP)及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平的影响。方法:102例2型糖尿病合并脑梗死患者按随机数字表法将其分为观察组(51例)和对照组(51例)。对照组给予常规西药治疗,观察组在对照组基础上给予补阳还五汤治疗。比较两组患者临床疗效,hs-CRP、TNF-α水平,中医证候积分,神经功能缺损评分以及不良反应。结果:治疗后观察组有效率为92.16%,对照组有效率为70.59%,两组有效率比较,差异有统计学意义(P<0.05)。治疗前两组患者血清hs-CRP、TNF-α水平无显著差异(P>0.05);治疗后均显著降低(P<0.05),观察组显著低于对照组(P<0.05)。两组患者治疗前中医证候积分与神经功能缺损评分比较,差异无统计学意义(P>0.05);治疗后两组均显著降低(P<0.05),观察组显著低于对照组(P<0.05)。观察组患者不良反应发生率为7.84%,显著低于对照组的23.53%(P<0.05)。结论:补阳还五汤可以有效降低2型糖尿病合并脑梗死患者血清hs-CRP及TNF-α水平,同时改善患者中医证候和神经功能,减少不良反应的发生。
Objective： To explore the effects of Buyang Huanwu Decoction on serum levels of hs-CRP and TNF-αin patients with type 2 diabetes with cerebral infarction. Methods： 102 cases of patients with type 2 diabetes mellitus complicated with cerebral infarction in our hospital from June 2012 to June 2014 were selected as the research subjects,who were divided into experimental group（ 51 cases） and control group（ 51 cases） according to the random digital table. The control group was given conventional western medicine treatment,and the experimental group was given Buyang Huanwu Decoction in addition to that of the control group. The overall effects of the two groups were observed and compared after treatment and the levels of serum hs-CRP,TNF-αand scores of TCM syndrome,nerve function defect as well as the adverse reactions were compared. Results： After treatment,the overall efficacy of the experimental group was better than that of the control group. The total effective rate of the experimental group was 92. 16%,which was significantly higher than that（ 70. 59%） of the control group（ P〈0. 05）. There were no significant differences in the serum levels of hs-CRP and TNF-α between the two groups before treatment（ P〈0. 05）,but that were significantly lower respectively after treatment（ P〈0. 05）. The serum levels of hs-CRP and TNF-α in the experimental group were significantly lower than those in the control group（ P〈0. 05）. There were no significant differences in the TCM syndrome scores and neurological deficit scores between the two groups before treatment（ P〈0. 05）,while after treatment that was significantly reduced respectively（ P〈0. 05）. The scores in the experimental group were significantly lower than those of the control group（ P〈0. 05）. The incidence of adverse reactions in the experimental group was 7. 84%,which was significantly lower than that（ 23. 53%） of the control group（ P〈0. 05）. Conclusion： Buyang huanwu Decoction can effectively reduce the levels of serum hsCRP and TNF-αin patients with type 2 diabetes with cerebral infarction,improve the traditional Chinese medicine syndrome and neurological function. Besides,it can reduce the incidence of adverse reactions and has values for further application.
出处
《中医学报》
CAS
2018年第1期54-58,共5页
Acta Chinese Medicine
基金
湖北省自然科学基金项目(2010CDB09201)
关键词
补阳还五汤
2型糖尿病
脑梗死
超敏C反应蛋白
肿瘤坏死因子-Α
中西医结合
Buyang huanwu Decoction
Type 2 diabetes
Cerebral infarction
high sensitive C reactive protein
Tumor necrosis factor-α
Integrative medicine
