摘要
目的:分析银杏叶提取物对慢性阻塞性肺疾病患者血栓前状态及气道重塑的作用,为银杏叶提取物的推广应用提供参考。方法:500例慢性阻塞性肺疾病患者随机分为对照组和观察组各250例。对照组患者常规给予糖皮质激素、支气管扩张剂、抗生素、祛痰剂等支持治疗,同时采用呼吸机行无创正压通气;观察组在对照组治疗基础上加用银杏叶提取物;两组均以10 d为1个疗程,连续治疗3个疗程。比较两组患者治疗前后肺功能、血栓前状态及气道重塑情况。结果:观察组与对照组治疗后的第1秒用力呼气量(forced expiratory volume in first second,FEV1)%和FEV1/用力肺活量(forced vital capacity,FVC)均明显高于治疗前(P<0.05);治疗后观察组FEV1和FEV1/FVC均显著高于对照组(P<0.05)。治疗后观察组与对照组动脉血氧饱和度均显著提高,而呼吸暂停低通气指数明显降低(P<0.05);治疗后观察组的动脉血氧饱和度与呼吸暂停低通气指数与对照组比较,差异有统计学意义(P<0.05)。观察组与对照组治疗后的D-二聚体与纤维蛋白原水平明显低于治疗前(P<0.05);治疗后观察组的D-二聚体与纤维蛋白原水平也明显低于对照组(P<0.05)。所有患者至随访结束,观察组的住院时间与门诊次数分别为(2.11±1.03)d和(1.48±0.23)次,均明显少于对照组的(8.56±1.24)d和(3.45±0.22)次(P<0.05)。结论:银杏叶提取物治疗慢性阻塞性肺疾病疗效显著,能改善血栓前状态,促进气道重塑,从而有利于改善呼吸状态与肺功能,促进预后的提高。
Objective： To investigate the effect of Ginkgo biloba extract on pre-thrombotic state and airway remodeling in patients with chronic obstructive pulmonary disease,and to provide reference for the popularization and application of Ginkgo biloba extract. Methods： 500 patients with chronic obstructive pulmonary disease were randomly divided into control group and observation group,with 250 cases in each group. All patients in the control group were given conventional glucocorticoid,bronchodilator,antibiotics,expectorants and other supportive treatment as well as noninvasive positive pressure ventilation with ventilator; All patients in the observation group was treated with Ginkgo biloba extract in addition to that of the control group. Both groups were continuously treated for 3 courses,with 10 day as one course. The pulmonary function,pro-thrombotic state and airway remodeling between the two groups before and after treatment were examined and compared. Results： The forced expiratory volume in first second（ FEV1）and FEV1/forced vital capacity（ FVC） in observation group and control group were significantly higher than those before treatment（ P〈0. 05）. After treatment,FEV1 and FEV1/FVC in the observation group were significantly higher than those in the control group（ P〈0. 05）. After treatment,the arterial oxygen saturation in observation group and control group were significantly increased,while the apnea hypopnea index was significantly decreased（ P〈0. 05）. After treatment,arterial oxygen saturation and apnea-hypopnea index in the observation group were significantly lower than those in the control group（ P〈0. 05）. D-dimer and FIB in observation group and control group were significantly lower than those before treatment（ P〈0. 05）; D-dimer and FIB in observation group were also significantly lower than those in control group after treatment（ P〈0. 05）. All patients were followed up for a period. The length of stay in hospital and outpatient visits of the observation group were（ 2. 11 ± 1. 03） days and（ 1. 48 ±0. 23） days respectively,which were significantly less than those of the control group,namely,（ 8. 56 ± 1. 24） days and（ 3. 45 ±0. 22） days respectively（ P〈0. 05）. Conclusion： Ginkgo biloba extract is effective in treating for chronic obstructive pulmonary disease,which can improve the pre-thrombotic state,promote airway remodeling and is beneficially effective to improve patients＇ respiratory status,lung function and prognosis.
出处
《中医学报》
CAS
2018年第1期42-46,共5页
Acta Chinese Medicine
基金
国家科技支撑计划项目(2011BA04B03)
关键词
银杏叶提取物
慢性阻塞性肺疾病
血栓前状态
气道重塑
肺功能
中西医结合
Ginkgo biloba extract
chronic obstructive pulmonary disease
pre thrombotic state
airway remodeling
pulmonary function
Integrative medicine
