摘要
目的:采用循证医学的方法总结分析与中药治疗原发性不宁腿综合征临床实践相关的循证证据,为今后临床研究决策提供方向和参考。方法:基于中药治疗原发性不宁综合征临床实践中常见的重要问题,全面检索当前可得的临床研究文献,采用GRADE系统对文献证据质量进行分级,从高到低选用能够回答相应临床问题的证据,采用Rev Man5.3统计结局指标。结果:符合纳入标准的文献有34篇。1项高级证据(A级)证据表明中药治疗原发性不宁腿综合征的有效性,1项高级证据(A级)和2项低级证据(C级)表明中药可能优于西药。3项低级证据(C级)表明中药配合西药有协同增效的作用。1项高级证据(A级),2项低级证据(C级)表明中药治疗原发性不宁腿综合征不良反应较少或与西药相当。结论:就目前来看,中药治疗原发性不宁腿综合征安全有效,中西药并用的效果可能更佳,但仍需更多高质量临床证据证实。
Objective： Evidence based medicine was used to summarize and analyze the evidence-based evidence related to the clinical practice of Traditional Chinese Medicine in the treatment of primary restless leg syndrome,and to provide direction and reference for future clinical research. Methods： Based on common important problems in the clinical practice of the treatment of primary restless syndrome with traditional Chinese medicine,A comprehensive review of current available clinical studies was conducted. The quality of the evidence was graded using GRADE system,and evidence from the high to low was used to answer the relevant clinical questions,The Cochrane Collaboration＇s Rev Man5. 3 software was used for data analyses. Results： There are 34 articles that meet the inclusion criteria. 1 high-level evidence（ A-level） evidence suggests the effectiveness of traditional Chinese medicine in the treatment of primary restless legs syndrome. 1 advanced evidence（ class A） and 2 lower level of evidence（ class C） indicate that Chinese medicine may be superior to Western medicine in curative effect. 3 lower levels of evidence（ class C） show that traditional Chinese medicine and Western medicine have synergistic effect. 1 high-level evidence（ class A）,2 low level of evidence（ class C） showed that traditional Chinese medicine treatment of primary restless legs syndrome adverse reactions were less or equivalent to Western medicine. Conclusion：At present,traditional Chinese medicine is safe and effective in the treatment of primary restless legs syndrome. The effect of combination of Chinese medicine and Western medicine may be better,but more high-quality clinical evidence is needed to confirm it.
出处
《江西中医药大学学报》
2018年第1期18-21,25,共5页
Journal of Jiangxi University of Chinese Medicine
基金
国家中医药管理局全国名老中医药专家传承工作室建设项目-饶旺福全国名老中医药专家传承工作室
江西省卫生计生委中医药科研计划项目(2015A163)
关键词
中药治疗
原发性不宁腿综合征
临床证据
证据等级
Traditional Chinese Medicine Treatment
Primary Restless Legs Syndrome
Clinical Evidence
Level of Evidence
