摘要
目的观察醒脑静注射液对急性脑出血后脑水肿和血清神经元特异烯醇化酶(NSE)水平的影响。方法选择2014年6月—2016年3月江苏省昆山市第一人民医院神经内科治疗的急性脑出血患者94例作为研究对象,依据就诊单双号随机划分为观察组与对照组各47例。依照患者的身体状况注射甘油果糖、呋塞米或者甘露醇等具有脱水降颅压作用的注射液;观察组患者在此基础上加用醒脑静注射液。治疗7 d后,对比2组患者出血后脑水肿、神经功能恢复及血清NSE、C反应蛋白(CRP)水平情况。结果观察组总有效率为91.49%,高于对照组的76.59%(X^2=3.887,P=0.048);治疗后,观察组的NIHSS评分低于对照组[(3.46±0.61)分vs.(5.73±0.82)分,t=15.271,P<0.01];观察组的脑水肿量和水肿体积高于对照组[(2.19±0.54)ml vs.(4.16±0.85)ml,t=13.471,P=0.000;(2.37±0.74)ml vs.(4.06±1.03)ml.t=9.165,P=0.000];治疗后第7天,观察组NSE、CRP水平低于对照组[(6.47±3.23)μg/L vs.(13.01±2.76)μg/L,t=10.533,P=0.000;(5.76±2.41)pg/L vs.(12.70±2.84)μg/L,t=12.773,P=0.000]、结论醒脑静注射液治疗急性脑出血的疗效明显,不但可以有效地减少脑水肿,快速恢复患者的脑神经功能,还能降低血清NSE水平,改善患者预后,值得临床治疗中广泛应用。
Objective To investigate the effects of Xingnaojing injection on cerebral edema and serum NSE Levels after cerebral hemorrhage in the elderly. Methods Ninety-four patients of acute cerebral hemorrhage who received therapy from June 2014 to March 2016 in First People＇s Hospital of Kunshan City, Jiangsu Province were selected as research objects. According to the treatment of single and double number, they were divided into observation group and control group. According to the patient＇s physical condition, they were given to the injection of glycerol fructose, furosemide or mannitol and other dehydration under the effect of intracranial pressure injection. Observation group of patients on this basis plus Xingnaojing injection. The cerebral edema, neurological function recovery and serum NSE levels were compared between the two groups after hemorrhage. Results The total effective rate was 91.49%, which was higher in the observation group than in the control group 76.59% （χ^2 = 3. 887, P = 0. 048）. After treatment, the NIHSS score of the observation group was lower than that of the control group [ （3.46 ± 0.61 ） vs. （5.73 ±0.82）, t = 15. 227, P 〈 0.05 ]. The edema volume and edema volume of the observation group and the control group were compared[ （2.19 ± 0.54 ） ml vs. （4.16 ± 0.85 ） ml, t = 13. 471, P = 0. 000, （ 2.37 ± 0.74） ml vs. （4.06 ±1.03） ml, t = 9. 165, P = 0. 000 ], the difference was statistically significant; On the 7th day after treatment,the NSE, CRP of the observation group compared with the control group, [ （ 6. 47± 3. 23 ） μg/L vs. （ 13. 01 ± 2.76）μg/L, t = 10.533, P 〈 0.05, （5.76 ± 2.41 ） pg/L vs. （ 12.70± 2.84 ） μg/L, t = 12.773, P = 0. 000 ]. Conclusion Xingnaojing injection on the treatment of cerebral hemorrhage effect is obvious, not only can effectively smaller brain edema, rapid recovery of the patient＇s brain function, reduce serum NSE secretion, improve patient prognosis. Worthy of extensive clinical use in the future.
出处
《疑难病杂志》
CAS
2018年第1期38-41,共4页
Chinese Journal of Difficult and Complicated Cases
